| RUNX1 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1CMO, 1CO1, 1E50, 1H9D, 1LJM | | |
| Ідентифікатори |
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| Символи | RUNX1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, runt related transcription factor 1, RUNX family transcription factor 1 |
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| Зовнішні ІД | OMIM: 151385 MGI: 99852 HomoloGene: 1331 GeneCards: RUNX1 |
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| Пов'язані генетичні захворювання |
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| натуральна віспа, рак стравоходу, hereditary thrombocytopenia with normal platelets-hematological cancer predisposition syndrome, гострий мієлоїдний лейкоз[1] |
| Онтологія гена |
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| Молекулярна функція | • DNA binding
• calcium ion binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• protein homodimerization activity
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• transcription factor binding
• GO:0001948, GO:0016582 protein binding
• protein heterodimerization activity
• ATP binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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| Клітинна компонента | • внутрішньоклітинна мембранна органела
• клітинне ядро
• гіалоплазма
• нуклеоплазма
• core-binding factor complex
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| Біологічний процес | • peripheral nervous system neuron development
• myeloid cell differentiation
• GO:0009373 regulation of transcription, DNA-templated
• chondrocyte differentiation
• осифікація
• negative regulation of granulocyte differentiation
• hematopoietic stem cell proliferation
• transcription, DNA-templated
• positive regulation of angiogenesis
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• positive regulation of interleukin-2 production
• positive regulation of granulocyte differentiation
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• transcription by RNA polymerase II
• regulation of cytokine-mediated signaling pathway
• regulation of Wnt signaling pathway
• regulation of intracellular estrogen receptor signaling pathway
• regulation of regulatory T cell differentiation
• regulation of keratinocyte differentiation
• regulation of myeloid cell differentiation
• regulation of megakaryocyte differentiation
• regulation of B cell receptor signaling pathway
• regulation of hematopoietic stem cell differentiation
• regulation of bicellular tight junction assembly
• кровотворення
• GO:1901227 negative regulation of transcription by RNA polymerase II
• negative regulation of CD4-positive, alpha-beta T cell differentiation
• positive regulation of CD8-positive, alpha-beta T cell differentiation
• negative regulation of gene expression
• neuron differentiation
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001001890
NM_001122607
NM_001754 |
| | NM_001111021
NM_001111022
NM_001111023
NM_009821 |
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| RefSeq (білок) | | NP_001001890
NP_001116079
NP_001745 |
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| Локус (UCSC) | Хр. 21: 34.79 – 36 Mb | Хр. 16: 92.4 – 92.62 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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