| GATA4 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Ідентифікатори |
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| Символи | GATA4, GATA binding protein 4, ASD2, TACHD, VSD1, TOF |
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| Зовнішні ІД | OMIM: 600576 MGI: 95664 HomoloGene: 1551 GeneCards: GATA4 |
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| Пов'язані генетичні захворювання |
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| короткозорість, atrial heart septal defect 2, тетрада Фалло, testicular anomalies with or without congenital heart disease, атріосептальний дефект, ventricular septal defect 1[1] |
| Онтологія гена |
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| Молекулярна функція | • DNA binding
• sequence-specific DNA binding
• co-SMAD binding
• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001105 transcription coactivator activity
• zinc ion binding
• transcription factor binding
• chromatin binding
• зв'язування з іоном металу
• GO:0001948, GO:0016582 protein binding
• GO:0001158 cis-regulatory region sequence-specific DNA binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• protein kinase binding
• NFAT protein binding
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
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| Клітинна компонента | • нуклеоплазма
• RNA polymerase II transcription regulator complex
• клітинне ядро
• ядерні тільця
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| Біологічний процес | • endoderm development
• male gonad development
• GO:0009373 regulation of transcription, DNA-templated
• ventricular septum development
• cell growth involved in cardiac muscle cell development
• embryonic foregut morphogenesis
• endocardial cushion development
• cardiac muscle cell differentiation
• cell-cell signaling
• response to mechanical stimulus
• зсідання крові
• transcription by RNA polymerase II
• transcription, DNA-templated
• positive regulation of angiogenesis
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• heart looping
• atrial septum morphogenesis
• response to vitamin A
• regulation of cardiac muscle cell contraction
• atrial septum secundum morphogenesis
• atrial septum primum morphogenesis
• intestinal epithelial cell differentiation
• embryonic heart tube anterior/posterior pattern specification
• positive regulation of BMP signaling pathway
• positive regulation of cardioblast differentiation
• positive regulation of vascular endothelial growth factor production
• negative regulation of autophagy
• cardiac ventricle morphogenesis
• cardiac right ventricle morphogenesis
• cellular response to glucose stimulus
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• transdifferentiation
• aortic valve morphogenesis
• heart development
• animal organ morphogenesis
• гістогенез
• розвиток клітин
• anatomical structure formation involved in morphogenesis
• digestive tract development
• cardiac muscle tissue development
• atrioventricular valve formation
• negative regulation of cardiac muscle cell apoptotic process
• regulation of protein kinase B signaling
• cardiac muscle tissue regeneration
• positive regulation of ERK1 and ERK2 cascade
• negative regulation of oxidative stress-induced cell death
• negative regulation of apoptotic signaling pathway
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | ENSG00000136574
ENSG00000285109 |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001308093
NM_001308094
NM_002052
NM_001374273
NM_001374274 |
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| RefSeq (білок) | | NP_001295022
NP_001295023
NP_002043
NP_001361202
NP_001361203 |
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| Локус (UCSC) | Хр. 8: 11.68 – 11.76 Mb | Хр. 14: 63.44 – 63.51 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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