| GLI3 |
|---|
|
| Наявні структури |
|---|
| PDB | Пошук ортологів: PDBe RCSB |
|---|
| |
| Ідентифікатори |
|---|
| Символи | GLI3, ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV, GLI family zinc finger 3 |
|---|
| Зовнішні ІД | OMIM: 165240 MGI: 95729 HomoloGene: 139 GeneCards: GLI3 |
|---|
| |
| Пов'язані генетичні захворювання |
|---|
| макулодистрофія, поліноз, Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome[1] |
| Онтологія гена |
|---|
| Молекулярна функція | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
• GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
• histone deacetylase binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• зв'язування з іоном металу
• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• beta-catenin binding
• chromatin binding
• GO:0001948, GO:0016582 protein binding
• histone acetyltransferase binding
• nucleic acid binding
• DNA binding
• sequence-specific DNA binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• mediator complex binding
|
|---|
| Клітинна компонента | • цитоплазма
• гіалоплазма
• transcription repressor complex
• клітинне ядро
• nuclear speck
• cell projection
• mediator complex
• війка
• GO:0035085 Аксонема
• нуклеоплазма
• ciliary base
• ciliary tip
|
|---|
| Біологічний процес | • embryonic skeletal system morphogenesis
• pattern specification process
• lateral semicircular canal development
• negative regulation of neuron differentiation
• T cell differentiation in thymus
• tongue development
• nose morphogenesis
• optic nerve morphogenesis
• smoothened signaling pathway involved in ventral spinal cord interneuron specification
• anatomical structure formation involved in morphogenesis
• oligodendrocyte differentiation
• hindgut morphogenesis
• spinal cord dorsal/ventral patterning
• thymocyte apoptotic process
• mammary gland development
• limb development
• odontogenesis of dentin-containing tooth
• positive regulation of chondrocyte differentiation
• embryonic digestive tract morphogenesis
• inner ear development
• metanephros development
• melanocyte differentiation
• negative regulation of canonical Wnt signaling pathway
• negative regulation of cell population proliferation
• regulation of apoptotic process
• positive regulation of neuroblast proliferation
• GO:0009373 regulation of transcription, DNA-templated
• limb morphogenesis
• negative regulation of smoothened signaling pathway
• розвиток нирки
• lung development
• tube development
• embryonic organ development
• lateral ganglionic eminence cell proliferation
• negative regulation of cell differentiation
• embryonic digit morphogenesis
• negative regulation of alpha-beta T cell differentiation
• in utero embryonic development
• transcription, DNA-templated
• negative thymic T cell selection
• GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
• heart development
• central nervous system development
• telencephalon development
• branching involved in ureteric bud morphogenesis
• embryonic limb morphogenesis
• neural tube development
• positive regulation of protein import into nucleus
• smoothened signaling pathway
• camera-type eye development
• spinal cord motor neuron differentiation
• positive regulation of alpha-beta T cell differentiation
• lambdoid suture morphogenesis
• regulation of bone development
• roof of mouth development
• proximal/distal pattern formation
• GO:1903374 anatomical structure development
• Загоєння ран
• negative regulation of apoptotic process
• GO:1901227 negative regulation of transcription by RNA polymerase II
• response to estrogen
• cerebral cortex radial glia-guided migration
• positive regulation of osteoblast differentiation
• developmental growth
• pallium development
• mammary gland specification
• frontal suture morphogenesis
• anterior semicircular canal development
• регуляція експресії генів
• GO:0045996 negative regulation of transcription, DNA-templated
• dorsal/ventral pattern formation
• branching morphogenesis of an epithelial tube
• embryonic digestive tract development
• subpallium development
• sagittal suture morphogenesis
• forebrain dorsal/ventral pattern formation
• protein processing
• axon guidance
• brain development
• smoothened signaling pathway involved in dorsal/ventral neural tube patterning
• forebrain radial glial cell differentiation
• regulation of cell population proliferation
• smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
• layer formation in cerebral cortex
• embryonic morphogenesis
• artery development
• cell differentiation involved in kidney development
• регуляція диференціювання клітин
• forebrain development
• neuron fate commitment
• hippocampus development
• camera-type eye morphogenesis
• anterior/posterior pattern specification
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• transcription by RNA polymerase II
• prostate gland development
• liver regeneration
|
|---|
| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
|---|
 |
| Більше даних |
| Ортологи |
|---|
| Види | Людина | Миша |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (мРНК) | | |
|---|
| RefSeq (білок) | | |
|---|
| Локус (UCSC) | Хр. 7: 41.96 – 42.26 Mb | Хр. 13: 15.64 – 15.9 Mb |
|---|
| PubMed search | [2] | [3] |
|---|
| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
|
