GLI2 |
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Ідентифікатори |
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Символи | GLI2, CJS, HPE9, PHS2, THP1, THP2, GLI family zinc finger 2 |
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Зовнішні ІД | OMIM: 165230 MGI: 95728 HomoloGene: 12725 GeneCards: GLI2 |
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Пов'язані генетичні захворювання |
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рак простати, еректильна дисфункція, holoprosencephaly 9, postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome[1] |
Онтологія гена |
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Молекулярна функція | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • зв'язування з іоном металу • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • zinc ion binding • chromatin binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • sequence-specific DNA binding • DNA binding • transcription factor binding • promoter-specific chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific |
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Клітинна компонента | • цитоплазма • гіалоплазма • мембрана • клітинне ядро • nuclear speck • GO:0035085 Аксонема • нуклеоплазма • ciliary base • ciliary tip • ядерце • motile cilium • війка • cell projection |
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Біологічний процес | • pattern specification process • skeletal system development • smoothened signaling pathway involved in ventral spinal cord interneuron specification • notochord regression • anatomical structure formation involved in morphogenesis • hindgut morphogenesis • spinal cord dorsal/ventral patterning • transcription by RNA polymerase II • mammary gland development • odontogenesis of dentin-containing tooth • prostatic bud formation • negative regulation of chondrocyte differentiation • cerebellar cortex morphogenesis • проліферація • spinal cord ventral commissure morphogenesis • cellular response to virus • floor plate formation • GO:0009373 regulation of transcription, DNA-templated • розвиток нирки • lung development • tube development • response to mechanical stimulus • embryonic digit morphogenesis • head development • neuron development • in utero embryonic development • transcription, DNA-templated • mammary gland duct morphogenesis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • morphogenesis of an epithelium • ventral midline development • heart development • positive regulation of neuron differentiation • neural tube development • smoothened signaling pathway • spinal cord motor neuron differentiation • epidermal cell differentiation • proximal/distal pattern formation • диференціація клітин • positive regulation of T cell differentiation in thymus • chondrocyte differentiation • GO:1903374 anatomical structure development • smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation • GO:1904579 cellular response to organic cyclic compound • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of DNA replication • developmental growth • osteoblast differentiation • osteoblast development • dorsal/ventral neural tube patterning • dorsal/ventral pattern formation • branching morphogenesis of an epithelial tube • embryonic digestive tract development • pituitary gland development • hindbrain development • ventral spinal cord development • axon guidance • multicellular organism development • regulation of smoothened signaling pathway • smoothened signaling pathway involved in dorsal/ventral neural tube patterning • smoothened signaling pathway involved in spinal cord motor neuron cell fate specification • cochlea morphogenesis • positive regulation of cell population proliferation • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • prostate gland development |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_005270 NM_030379 NM_030380 NM_030381 NM_001371271
| NM_001374353 NM_001374354 |
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RefSeq (білок) | | NP_005261 NP_001358200 NP_001361282 NP_001361283 |
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Локус (UCSC) | Хр. 2: 120.74 – 120.99 Mb | Хр. 1: 118.76 – 118.98 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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