GRIN1 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2HQW, 2NR1, 3BYA, 5H8N, 5H8H, 5H8Q, 5H8F, 5I2N, 5I2K, 5KCJ, 5KDT | | |
Ідентифікатори |
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Символи | GRIN1, GluN1, MRD8, NMDA1, NMDAR1, NR1, NMD-R1, glutamate ionotropic receptor NMDA type subunit 1, NDHMSR, NDHMSD, DEE101 |
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Зовнішні ІД | OMIM: 138249 MGI: 95819 HomoloGene: 7187 GeneCards: GRIN1 |
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Пов'язані генетичні захворювання |
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autosomal dominant non-syndromic intellectual disability 8[1] |
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Реагує на сполуку |
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Гліцин, Аспарагінова кислота, Tetrazolylglycine, N-метил-D-аспартат, homoquinolinic acid, 5,7-dichlorokynurenic acid, lanicemine, CERC-301, neboglamine, priralfinamide, esketamine, кетамін, cns-5161, ketamine hydrochloride, amantadine hydrochloride, orphenadrine citrate[2] |
Онтологія гена |
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Молекулярна функція | • calcium ion binding • signaling receptor binding • glycine binding • calmodulin binding • GO:0001948, GO:0016582 protein binding • cation channel activity • extracellularly glutamate-gated ion channel activity • glutamate binding • calcium channel activity • NMDA glutamate receptor activity • ion channel activity • ionotropic glutamate receptor activity • neurotransmitter binding • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential • amyloid-beta binding • glutamate-gated calcium ion channel activity • signaling receptor activity • GO:0032403 protein-containing complex binding |
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Клітинна компонента | • цитоплазма • postsynaptic membrane • мембрана • синапс • NMDA selective glutamate receptor complex • neuron projection • Синаптичні бульбашки • dendritic spine • cell surface • ендоплазматичний ретикулум • integral component of membrane • клітинна мембрана • GO:0097483, GO:0097481 постсинаптичне ущільнення • integral component of plasma membrane • excitatory synapse • міжклітинні контакти • дендрит (нейробіологія) • synaptic cleft • terminal bouton • postsynaptic density membrane • synaptic membrane • glutamatergic synapse • integral component of postsynaptic density membrane |
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Біологічний процес | • GO:1904089 negative regulation of neuron apoptotic process • pons maturation • synaptic transmission, glutamatergic • regulation of respiratory gaseous exchange • response to amphetamine • regulation of membrane potential • regulation of synapse assembly • навчення • positive regulation of excitatory postsynaptic potential • response to ethanol • calcium ion transport • suckling behavior • prepulse inhibition • male mating behavior • regulation of long-term neuronal synaptic plasticity • adult locomotory behavior • regulation of neuron apoptotic process • ion transport • пам'ять • regulation of axonogenesis • neuromuscular process • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • learning or memory • соціальна поведінка • regulation of neuronal synaptic plasticity • associative learning • переляк • calcium ion homeostasis • cation transport • cellular calcium ion homeostasis • cation transmembrane transport • respiratory gaseous exchange by respiratory system • regulation of synaptic plasticity • response to morphine • propylene metabolic process • conditioned taste aversion • cerebral cortex development • GO:0015915 транспорт • sensory perception of pain • olfactory learning • regulation of cell communication • visual learning • ephrin receptor signaling pathway • MAPK cascade • regulation of dendrite morphogenesis • ion transmembrane transport • довготривала пам'ять • positive regulation of apoptotic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • calcium ion transmembrane transport • regulation of ion transmembrane transport • brain development • positive regulation of calcium ion transport into cytosol • calcium-mediated signaling • protein heterotetramerization • GO:0060401 calcium ion transmembrane import into cytosol • excitatory chemical synaptic transmission • positive regulation of reactive oxygen species biosynthetic process • protein localization to postsynaptic membrane • cellular response to amyloid-beta • response to glycine • positive regulation of cysteine-type endopeptidase activity • regulation of NMDA receptor activity |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569 |
| NM_001177656 NM_001177657 NM_008169 NM_001372558 NM_001372559
| NM_001372560 NM_001372561 NM_001372562 |
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RefSeq (білок) | | NP_000823 NP_001172019 NP_001172020 NP_015566 NP_067544 |
| NP_001171127 NP_001171128 NP_032195 NP_001359487 NP_001359488
| NP_001359489 NP_001359490 NP_001359491 |
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Локус (UCSC) | Хр. 9: 137.14 – 137.17 Mb | Хр. 2: 25.18 – 25.21 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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