PDGFB |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Protein_PDGFB_PDB_1pdg.png/220px-Protein_PDGFB_PDB_1pdg.png) |
بنى متوفرة |
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بنك بيانات البروتين | Ortholog search: PDBe RCSB | قائمة رموز معرفات بنك بيانات البروتين | 1PDG, 3MJG, 4HQU, 4HQX, 4QCI | | |
معرفات |
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أسماء بديلة | PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B |
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معرفات خارجية | الوراثة المندلية البشرية عبر الإنترنت 190040 MGI: MGI:97528 HomoloGene: 74303 GeneCards: 5155 |
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علم الوجود الجيني |
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وظائف جزيئية | • protein homodimerization activity • protein heterodimerization activity • chemoattractant activity • platelet-derived growth factor receptor binding • platelet-derived growth factor binding • superoxide-generating NADPH oxidase activator activity • growth factor activity • identical protein binding • collagen binding • GO:0001948، GO:0016582 ربط بروتيني • phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
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مكونات خلوية | • platelet alpha granule lumen • سيتوبلازم • الفراغ خارج الخلية • Golgi membrane • basolateral plasma membrane • cell surface • endoplasmic reticulum lumen • غشاء • GO:0005578 نسيج بيني خارج الخلية • خارج خلوي • تجويف غولجي • collagen-containing extracellular matrix |
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عمليات حيوية | • activation of protein kinase B activity • positive regulation of DNA biosynthetic process • positive regulation of chemotaxis • cellular response to growth factor stimulus • positive regulation of protein tyrosine kinase activity • peptidyl-tyrosine phosphorylation • positive regulation of cell division • نماء القلب • positive regulation of glomerular filtration • positive regulation of mitotic nuclear division • positive regulation of MAP kinase activity • positive regulation of metanephric mesenchymal cell migration • positive regulation of hyaluronan biosynthetic process • MAPK cascade • protein phosphorylation • positive regulation of glomerular mesangial cell proliferation • cellular response to mycophenolic acid • positive regulation of fibroblast proliferation • activation of protein kinase activity • نمو متعدد الخلايا • positive regulation of protein autophosphorylation • positive regulation of reactive oxygen species metabolic process • عملية التمثيل الغذائي لأنواع الأكسجين التفاعلية • GO:0045996 negative regulation of transcription, DNA-templated • protein kinase C signaling • metanephric glomerular mesangial cell development • negative regulation of phosphatidylinositol biosynthetic process • response to wounding • positive regulation of phosphatidylinositol 3-kinase activity • cell chemotaxis • positive regulation of ERK1 and ERK2 cascade • platelet degranulation • ضبط زيادي للتكاثر الخلوي • positive regulation of DNA replication • GO:1901313 positive regulation of gene expression • embryonic placenta development • تأشير نظير صماوي • monocyte chemotaxis • positive regulation of endothelial cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of calcium ion import • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated • GO:0035404 peptidyl-serine phosphorylation • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • positive regulation of blood vessel endothelial cell migration • تكون الدم • positive regulation of cell migration • positive regulation of peptidyl-tyrosine phosphorylation • extracellular matrix organization • negative regulation of protein binding • positive regulation of MAPK cascade • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of platelet activation • phosphatidylinositol phosphate biosynthetic process • positive regulation of vascular associated smooth muscle cell migration • positive chemotaxis • negative regulation of vascular associated smooth muscle cell differentiation • interleukin-18-mediated signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of gene expression • positive regulation of smooth muscle cell migration • positive regulation of smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell dedifferentiation • platelet-derived growth factor receptor signaling pathway • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of platelet-derived growth factor receptor-beta signaling pathway • regulation of signaling receptor activity • positive regulation of protein kinase B signaling |
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المصادر:Amigo / QuickGO | |
نمط التعبير عن الحمض النووي الريبوزي |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/77/PBB_GE_PDGFB_217112_at_fs.png/220px-PBB_GE_PDGFB_217112_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/5/53/PBB_GE_PDGFB_216061_x_at_fs.png/220px-PBB_GE_PDGFB_216061_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/0/04/PBB_GE_PDGFB_204200_s_at_fs.png/220px-PBB_GE_PDGFB_204200_s_at_fs.png) |
المزيد من بيانات التعبير المرجعية |
تماثلات متسلسلة |
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أنواع | الإنسان | الفأر |
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أنتريه | 5155 | 18591 |
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Ensembl | ENSG00000100311 | ENSMUSG00000000489 |
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يونيبروت | | |
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RefSeq (رنا مرسال.) | | NM_002608، XM_047441393، XM_047441394 NM_033016، NM_002608، XM_047441393، XM_047441394 |
| | XM_006520592، XM_017316502 NM_011057، XM_006520592، XM_017316502 |
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RefSeq (بروتين) | | NP_148937 NP_002599، NP_148937 |
| | XP_006520655، XP_030104269، XP_030104270، XP_030104271، XP_036015133، XP_036015134 NP_035187، XP_006520655، XP_030104269، XP_030104270، XP_030104271، XP_036015133، XP_036015134 |
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الموقع (UCSC | n/a | Chr 15: 80 – 80.01 Mb |
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بحث ببمد | [1] | [2] |
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ويكي بيانات |
اعرض/عدّل إنسان | اعرض/عدّل فأر |
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