UGT2A1 |
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Identifikatori |
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Alijasi | UGT2A1 |
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Spoljašnji ID | OMIM: 604716 MGI: 2149905 HomoloGene: 136808 GeneCards: UGT2A1 |
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Genska lokacija (miš) |
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![Chromosome 5 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png) | Hr. | Chromosome 5 (mouse)[1] |
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| Band | 5|5 E1 | Start | 87,607,349 bp[1] |
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Kraj | 87,638,730 bp[1] |
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Genska ontologija |
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Molecular function | • glycosyltransferase activity • transferase activity • glucuronosyltransferase activity • hexosyltransferase activity • UDP-glycosyltransferase activity
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Cellular component | • саставни део мембране • intracellular membrane-bounded organelle • мембрана
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Biological process | • sensory perception of smell • detection of chemical stimulus • Glukuronidacija • одговор на надражај • метаболизам
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Sources:Amigo / QuickGO |
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Ortolozi |
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Vrste | Čovek | Miš |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001252274 NM_001252275 NM_001301239 NM_006798 NM_001389565 |
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RefSeq (protein) | NP_001099147 NP_001288162 NP_001239203 NP_001239204 NP_001288168
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NP_006789 |
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Location (UCSC) | n/a | Chr 5: 87.61 – 87.64 Mb |
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PubMed search | [2] | [3] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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UDP glukuronoziltransferaza 2 familija, polipeptid B1, takođe poznata kao UGT2B1, je enzim koji je kod ljudi kodiran genom UGT2B1.[4][5]
Funkcija
Olfaktorni neuroepitel, koji oblaže zadnji deo nosne šupljine, izložen je širokom spektru mirisa i toksičnih jedinjenja u vazduhu. Odoranti, koji su uglavnom mali lipofilni molekuli, ulaze u tok sluzi i dospevaju do receptora mirisa na senzornim neuronima. Osećaj mirisa je generalno prolazan proces, koji zahteva efikasan završetak signala, koji se može obezbediti biotransformacijom mirisa u ćelijama koje podržavaju epitel. Smatra se da enzimi koji metabolišu ksenobiotike u olfaktornom epitelu katalizuju inaktivaciju i olakšavaju eliminaciju mirisa.[5] Nedavno je utvrđeno da UGT2A1 i UGT2A2 imaju ulogu u gubitku osećaja mirisa povezanom sa COVID-19.[6]
Reference
- ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000106677 - Ensembl, May 2017
- ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Jedlitschky G, Cassidy AJ, Sales M, Pratt N, Burchell B (јун 1999). „Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase”. Biochem. J. 340 (3): 837—43. PMC 1220318
. PMID 10359671. doi:10.1042/0264-6021:3400837. CS1 одржавање: Формат датума (веза) - ^ а б „Entrez Gene: UGT2B1 UDP glucuronosyltransferase 2 family, polypeptide B1”.
- ^ Shelton, Janie F.; Shastri, Anjali J.; Aslibekyan, Stella; Auton, Adam; Auton, Adam (2021). The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia.
Literatura
- Iida A, Saito S, Sekine A, et al. (2002). „Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8.”. J. Hum. Genet. 47 (10): 505—10. PMID 12376738. doi:10.1007/s100380200075
. - Tukey RH, Strassburg CP (2001). „Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract.”. Mol. Pharmacol. 59 (3): 405—14. PMID 11179432. S2CID 21500183. doi:10.1124/mol.59.3.405.
- Strassburg CP, Kneip S, Topp J, et al. (2000). „Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.”. J. Biol. Chem. 275 (46): 36164—71. PMID 10748067. doi:10.1074/jbc.M002180200
. - Heydel J, Leclerc S, Bernard P, et al. (2001). „Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis.”. Brain Res. Mol. Brain Res. 90 (1): 83—92. PMID 11376859. doi:10.1016/S0169-328X(01)00080-8.
- Saito A, Kawamoto M, Kamatani N (2009). „Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.”. J. Hum. Genet. 54 (6): 317—23. PMID 19343046. doi:10.1038/jhg.2009.31
. - Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). „Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.”. Nat. Genet. 41 (12): 1345—9. PMID 19898482. S2CID 21293339. doi:10.1038/ng.478.
- Mackenzie PI, Bock KW, Burchell B, et al. (2005). „Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.”. Pharmacogenet. Genomics. 15 (10): 677—85. PMID 16141793. doi:10.1097/01.fpc.0000173483.13689.56.
2.4.1: Heksozil- transferaze | |
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2.4.2: Pentozil- transferaze | |
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2.4.99: Sijalil transferaze | |
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