UDP-glukuronoziltransferaza 1-9 je enzim koji je kod ljudi kodiran genomUGT1A9.[4][5][6][7]
Interaktivna mapa putanja
Kliknite na gene, proteine i metabolite u nastavku za veze s odgovarajućim člancima.[§ 1]
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Irinotekanski put edit
^The interactive pathway map can be edited at WikiPathways: „IrinotecanPathway_WP46359”.
Medicinsko hemijski primeri
Tokom optimizacije inicijalnih inhibitora HSD17B13 primećena je značajna glukuronidacija fenolnog dela in vitro i in vivo.[8] UGT fenotipizacija je otkrila da je UGT1A9 glavni doprinosilac glukuronidaciji. Pored toga, sprovedene su studije tkivne raspodele kao i izlučivanja putem žuči.
Reference
^ абвGRCm38: Ensembl release 89: ENSMUSG00000090165 - Ensembl, May 2017
^„Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^„Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, Burchell B (септембар 1991). „Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family”. Biochem. J. 278 (2): 465—9. PMC 1151367 . PMID 1910331. doi:10.1042/bj2780465.CS1 одржавање: Формат датума (веза)
^Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (октобар 1997). „The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence”. Pharmacogenetics. 7 (4): 255—69. PMID 9295054. doi:10.1097/00008571-199708000-00001.CS1 одржавање: Формат датума (веза)
^Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (март 1992). „A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini”. J Biol Chem. 267 (5): 3257—61. PMID 1339448. doi:10.1016/S0021-9258(19)50724-4 .CS1 одржавање: Формат датума (веза)
^„Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science”. Journal of Medicinal Chemistry.
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