FUT2

FUT2
Identifikatori
AlijasiFUT2
Spoljašnji IDOMIM: 182100 MGI: 109374 HomoloGene: 10325 GeneCards: FUT2
Genska lokacija (miš)
Chromosome 7 (mouse)
Hr.Chromosome 7 (mouse)[1]
Chromosome 7 (mouse)
Genomska lokacija za FUT2
Genomska lokacija za FUT2
Band7 B3|7 29.41 cMStart45,298,015 bp[1]
Kraj45,315,818 bp[1]
Obrazac RNK izražavanja


More reference expression data
Genska ontologija
Molecular function• transferase activity
• galactoside 2-alpha-L-fucosyltransferase activity
• glycosyltransferase activity
• fucosyltransferase activity
Cellular component• саставни део мембране
• Golgi cisterna membrane
• Голџијев апарат
• extracellular exosome
• мембрана
Biological process• GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation
• L-fucose catabolic process
• fucosylation
• Метаболизам угљених хидрата
Sources:Amigo / QuickGO
Ortolozi
VrsteČovekMiš
Entrez

2524

14344

Ensembl

ENSG00000176920

ENSMUSG00000055978

UniProt

Q10981

Q9JL27

RefSeq (mRNA)

NM_001097638
NM_000511

NM_001271993
NM_018876

RefSeq (protein)

NP_000502
NP_001091107

NP_001258922
NP_061364

Location (UCSC)n/aChr 7: 45.3 – 45.32 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Galaktozid 2-alfa-L-fukoziltransferaza 2 je enzim koji je kod ljudi kodiran genom FUT2.[4][5] On utiče na sekretorni status ABO antigena.[6]

Približno 20% belaca su nesekretori zbog mutacija G428A i C571T u FUT2 i stoga imaju snažnu, iako ne apsolutnu zaštitu od norovirusa GII.4.

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000055978 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Ball SP, Tongue N, Gibaud A, Le Pendu J, Mollicone R, Gerard G, Oriol R (фебруар 1992). „The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9”. Ann Hum Genet. 55 (Pt 3): 225—33. PMID 1763885. S2CID 30777695. doi:10.1111/j.1469-1809.1991.tb00417.x. CS1 одржавање: Формат датума (веза)
  5. ^ „Entrez Gene: FUT2 fucosyltransferase 2 (secretor status included)”. 
  6. ^ „Names for H (ISBT 018) Blood Group Alleles” (PDF). www.isbtweb.org. Архивирано из оригинала (PDF) 2019-08-28. г. Приступљено 2019-10-13. 

Literatura

  • Reguigne-Arnould I; Couillin P; Mollicone R; et al. (1995). „Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19”. Cytogenet. Cell Genet. 71 (2): 158—62. PMID 7656588. doi:10.1159/000134098. 
  • Rouquier S; Lowe JB; Kelly RJ; et al. (1995). „Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locus-related DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus”. J. Biol. Chem. 270 (9): 4632—9. PMID 7876234. doi:10.1074/jbc.270.9.4632 Слободан приступ. 
  • Kelly RJ; Rouquier S; Giorgi D; et al. (1995). „Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype”. J. Biol. Chem. 270 (9): 4640—9. PMID 7876235. doi:10.1074/jbc.270.9.4640 Слободан приступ. 
  • Kudo T; Iwasaki H; Nishihara S; et al. (1996). „Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals”. J. Biol. Chem. 271 (16): 9830—7. PMID 8621666. doi:10.1074/jbc.271.16.9830 Слободан приступ. 
  • Koda Y, Soejima M, Liu Y, Kimura H (1996). „Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency”. Am. J. Hum. Genet. 59 (2): 343—50. PMC 1914724 Слободан приступ. PMID 8755920. 
  • Koda Y, Soejima M, Wang B, Kimura H (1997). „Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2)”. Eur. J. Biochem. 246 (3): 750—5. PMID 9219535. doi:10.1111/j.1432-1033.1997.t01-1-00750.x Слободан приступ. 
  • Koda Y; Soejima M; Johnson PH; et al. (1997). „Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system”. Biochem. Biophys. Res. Commun. 238 (1): 21—5. PMID 9299444. doi:10.1006/bbrc.1997.7232. 
  • Liu Y; Koda Y; Soejima M; et al. (1998). „Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa”. Hum. Genet. 103 (2): 204—10. PMID 9760207. S2CID 25253767. doi:10.1007/s004390050808. 
  • Domino SE, Zhang L, Lowe JB (2001). „Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract”. J. Biol. Chem. 276 (26): 23748—56. PMID 11323419. doi:10.1074/jbc.M100735200. 
  • Roos C, Kolmer M, Mattila P, Renkonen R (2002). „Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism”. J. Biol. Chem. 277 (5): 3168—75. PMID 11698403. doi:10.1074/jbc.M107927200 Слободан приступ. 
  • Milland J; Russell SM; Dodson HC; et al. (2002). „The cytoplasmic tail of alpha 1,3-galactosyltransferase inhibits Golgi localization of the full-length enzyme”. J. Biol. Chem. 277 (12): 10374—8. PMID 11777923. doi:10.1074/jbc.M111799200 Слободан приступ. 
  • Chang JG; Ko YC; Lee JC; et al. (2002). „Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation”. J. Hum. Genet. 47 (2): 60—5. PMID 11916003. doi:10.1007/s100380200001 Слободан приступ. 
  • Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899 Слободан приступ. 
  • Lindesmith L; Moe C; Marionneau S; et al. (2003). „Human susceptibility and resistance to Norwalk virus infection”. Nat. Med. 9 (5): 548—53. PMID 12692541. S2CID 28663420. doi:10.1038/nm860. 
  • Guo ZH; Xiang D; Zhu ZY; et al. (2004). „[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]”. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 21 (5): 417—21. PMID 15476160. 
  • Chen DP; Tseng CP; Wang WT; et al. (2005). „Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese”. Ann. Clin. Lab. Sci. 34 (3): 314—8. PMID 15487706. 
  • Pang H, Soejima M, Koda Y, Kimura H (2005). „A novel tetrameric short tandem repeat located in the 3' flanking region of the human ABO-secretor gene (FUT2) and association between FUT2 and FUT2/01 loci”. Hum. Biol. 76 (5): 789—95. PMID 15757249. S2CID 1201579. doi:10.1353/hub.2005.0008. 
  • Madjd Z; Parsons T; Watson NF; et al. (2006). „High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas”. Breast Cancer Res. 7 (5): R780—7. PMC 1242157 Слободан приступ. PMID 16168124. doi:10.1186/bcr1305. 
  • Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55—65. PMC 1356129 Слободан приступ. PMID 16344560. doi:10.1101/gr.4039406. 
  • п
  • р
  • у
2.4.1: Heksozil-
transferaze
Glukozil-
Galaktozil-
Glukuronozil-
Fukozil-
Manozil-
2.4.2: Pentozil-
transferaze
Riboza
ADP-riboziltransferaza
Fosforiboziltransferaza
Drugi
Drugi
2.4.99: Sijalil
transferaze