SH3BGRL3

Protein-coding gene in the species Homo sapiens

SH3BGRL3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1SJ6

Identifiers

Aliases

SH3BGRL3, HEL-S-297, SH3BP-1, TIP-B1, SH3 domain binding glutamate rich protein like 3

External IDs

OMIM: 615679; MGI: 1920973; HomoloGene: 41824; GeneCards: SH3BGRL3; OMA:SH3BGRL3 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.11	Start	26,280,086 bp^[1]
Band	1p36.11	End	26,281,522 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D2.3	Start	133,854,717 bp^[2]
Band	4\|4 D2.3	End	133,856,100 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

granulocyte

monocyte

mucosa of transverse colon

right lung

Descending thoracic aorta

ascending aorta

rectum

skin of abdomen

spleen

upper lobe of left lung

Top expressed in

granulocyte

mesenteric lymph nodes

seminal vesicula

thymus

zygote

tibiofemoral joint

spleen

epithelium of stomach

stroma of bone marrow

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	electron transfer activity protein-disulfide reductase activity
Cellular component	nucleus extracellular exosome cytoplasm nuclear body
Biological process	cell redox homeostasis electron transport chain
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


83442


73723

Ensembl


ENSG00000142669


ENSMUSG00000028843

UniProt


Q9H299


Q91VW3

RefSeq (mRNA)


NM_031286


NM_080559

RefSeq (protein)


NP_112576


NP_542126

Location (UCSC)

Chr 1: 26.28 – 26.28 Mb

Chr 4: 133.85 – 133.86 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

SH3 domain-binding glutamic acid-rich-like protein 3 is a protein that in humans is encoded by the SH3BGRL3 gene.^[5]

The 10.5kDa protein SH3 binding glutamic acid-rich protein-like 3 has an isoelectric point of 5.0. SH3 binding glutamic acid-rich (SH3BGR) gene is located to human chromosome 21. Two homologous genes, SH3BGRL and SH3BGRL3 are located to chromosome Xq13.3 and 1p34.3-35, respectively and code for small proteins similar to the N-terminal region of the SH3BGR protein.^[6] SH3BGRL3 protein shows a significant similarity to glutaredoxin 1 of E. coli, and all the three proteins are predicted to belong to thioredoxin-like protein family. Glutaredoxins (GRXs) are ubiquitous oxidoreductases, which catalyze the reduction of many intra-cellular protein disulfides and play an important role in many redox pathways. However, the SH3BGRL3 protein lacks the enzymatic function of glutaredoxins and may have a role as a regulator of redox activity.^[7]

Role in cancer

Proteins such as glutaredoxin and thioredoxin are reported as up-regulated in many cancers such as lung and pancreatic; they have been implicated in increased resistance of cancer cells to free-radicals. There is little current evidence which directly links SH3GRPL3 with survival in cancer cells, however the protein has recently been identified as up-regulated in glioblastoma multiforme compared to normal cerebral tissue on proteomic analysis.^[8] Studies of acute promyelocytic leukemia cell line NB4 have also reported up-regulation of the protein. Conversely, the related protein SH3BGRL is reported to be downregulated in fibroblasts, lymphoid cells, and splenic tumor cells transformed by the viral oncogene v-Rel.^[9] Co-expression of SH3BGRL with v-Rel in primary splenic lymphocytes reduced the number of colonies formed by 76%. Xu et al. reported SH3BGRPL3 protein as a post-translational modification of the 27kDa tumor necrosis factor alpha (TNF-α) inhibitory protein, TIP-B1. This protein is potentially involved in resistance of cells to the apoptosis-inducing effect of TNF-α.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142669 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028843 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3".
^ Egeo A, Mazzocco M, Arrigo P, Vidal-Taboada JM, Oliva R, Pirola B, Giglio S, Rasore-Quartino A, Scartezzini P (June 1998). "Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene". Biochem. Biophys. Res. Commun. 247 (2): 302–6. doi:10.1006/bbrc.1998.8763. PMID 9642120.
^ Mazzocco M, Maffei M, Egeo A, Vergano A, Arrigo P, Di Lisi R, Ghiotto F, Scartezzini P (May 2002). "The identification of a novel human homologue of the SH3 binding glutamic acid-rich (SH3BGR) gene establishes a new family of highly conserved small proteins related to Thioredoxin Superfamily". Gene. 291 (1–2): 233–9. doi:10.1016/S0378-1119(02)00602-9. PMID 12095696.
^ Khalil AA, James P (February 2007). "Biomarker discovery: a proteomic approach for brain cancer profiling". Cancer Sci. 98 (2): 201–13. doi:10.1111/j.1349-7006.2007.00374.x. PMC 11158801. PMID 17233837.
^ Majid SM, Liss AS, You M, Bose HR (February 2006). "The suppression of SH3BGRL is important for v-Rel-mediated transformation". Oncogene. 25 (5): 756–68. doi:10.1038/sj.onc.1209107. PMID 16186799.
^ Xu C, Zheng P, Shen S, Xu Y, Wei L, Gao H, Wang S, Zhu C, Tang Y, Wu J, Zhang Q, Shi Y (May 2005). "NMR structure and regulated expression in APL cell of human SH3BGRL3". FEBS Lett. 579 (13): 2788–94. doi:10.1016/j.febslet.2005.04.011. PMID 15907482.