SH3BGR

Protein-coding gene in the species Homo sapiens
SH3BGR
Identifiers
AliasesSH3BGR, 21-GARP, SH3 domain binding glutamate rich protein
External IDsOMIM: 602230; HomoloGene: 137201; GeneCards: SH3BGR; OMA:SH3BGR - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for SH3BGR
Genomic location for SH3BGR
Band21q22.2Start39,445,855 bp[1]
End39,515,506 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • skeletal muscle tissue

  • muscle of thigh

  • left ventricle

  • apex of heart

  • right auricle

  • right coronary artery

  • ascending aorta

  • Descending thoracic aorta

  • left coronary artery
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • SH3 domain binding
Cellular component
  • cytosol
Biological process
  • positive regulation of signal transduction
  • protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6450

n/a

Ensembl

ENSG00000185437

n/a

UniProt

P55822

n/a

RefSeq (mRNA)

NM_001001713
NM_007341
NM_001317740
NM_001317741
NM_001317742

n/a

RefSeq (protein)

NP_001001713
NP_001304669
NP_001304670
NP_001304671
NP_031367

n/a

Location (UCSC)Chr 21: 39.45 – 39.52 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

SH3 domain-binding glutamic acid-rich protein is a protein that in humans is encoded by the SH3BGR gene.[3][4]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185437 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Scartezzini P, Egeo A, Colella S, Fumagalli P, Arrigo P, Nizetic D, Taramelli R, Rasore-Quartino A (Mar 1997). "Cloning a new human gene from chromosome 21q22.3 encoding a glutamic acid-rich protein expressed in heart and skeletal muscle". Hum Genet. 99 (3): 387–92. doi:10.1007/s004390050377. PMID 9050928. S2CID 40468995.
  4. ^ "Entrez Gene: SH3BGR SH3 domain binding glutamic acid-rich protein".

Further reading

  • Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Sandri C, Di Lisi R, Picard A, et al. (2004). "Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region". Hum. Genet. 114 (5): 517–9. doi:10.1007/s00439-004-1088-8. PMID 14767758. S2CID 9986804.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jiang LQ, Wen SJ, Wang HY, Chen LY (2003). "Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system". Hypertens. Res. 25 (4): 647–52. doi:10.1291/hypres.25.647. PMID 12358155.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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