SH3BGRL

Protein-coding gene in the species Homo sapiens

SH3BGRL
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1U6T, 1WRY

Identifiers
AliasesSH3BGRL, HEL-S-115, SH3BGR, SH3 domain binding glutamate rich protein like
External IDsOMIM: 300190; MGI: 1930849; HomoloGene: 2275; GeneCards: SH3BGRL; OMA:SH3BGRL - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SH3BGRL
Genomic location for SH3BGRL
BandXq21.1Start81,202,102 bp[1]
End81,298,547 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for SH3BGRL
Genomic location for SH3BGRL
BandX|X DStart108,138,971 bp[2]
End108,241,479 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • seminal vesicula

  • tail of epididymis

  • monocyte

  • superficial temporal artery

  • saphenous vein

  • trabecular bone

  • urethra

  • lactiferous duct

  • germinal epithelium

  • popliteal artery
Top expressed in
  • medial ganglionic eminence

  • tunica media of zone of aorta

  • ascending aorta

  • olfactory epithelium

  • Epithelium of choroid plexus

  • aortic valve

  • carotid body

  • left lung lobe

  • calvaria

  • submandibular gland
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • SH3 domain binding
Cellular component
  • cytoplasm
  • extracellular exosome
  • nucleus
  • extracellular space
Biological process
  • positive regulation of signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6451

56726

Ensembl

ENSG00000131171

ENSMUSG00000031246

UniProt

O75368

Q9JJU8

RefSeq (mRNA)

NM_003022

NM_019989

RefSeq (protein)

NP_003013

NP_064373

Location (UCSC)Chr X: 81.2 – 81.3 MbChr X: 108.14 – 108.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SH3 domain-binding glutamic acid-rich-like protein is a protein that in humans is encoded by the SH3BGRL gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131171 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031246 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Egeo A, Mazzocco M, Arrigo P, Vidal-Taboada JM, Oliva R, Pirola B, Giglio S, Rasore-Quartino A, Scartezzini P (Jul 1998). "Identification and characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene". Biochem Biophys Res Commun. 247 (2): 302–6. doi:10.1006/bbrc.1998.8763. PMID 9642120.
  6. ^ "Entrez Gene: SH3BGRL SH3 domain binding glutamic acid-rich protein like".

Further reading

  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
  • Drutel G, Arrang JM, Diaz J, et al. (1996). "Cloning of OL1, a putative olfactory receptor and its expression in the developing rat heart". Recept. Channels. 3 (1): 33–40. PMID 8589991.
  • Yin L, Xiang Y, Zhu DY, et al. (2006). "Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins". Proteins. 61 (1): 213–6. doi:10.1002/prot.20523. PMID 16080146.
  • Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169. S2CID 26007149.
  • Majid SM, Liss AS, You M, Bose HR (2006). "The suppression of SH3BGRL is important for v-Rel-mediated transformation". Oncogene. 25 (5): 756–68. doi:10.1038/sj.onc.1209107. PMID 16186799. S2CID 42806147.
  • Schulze WX, Deng L, Mann M (2006). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): 2005.0008. doi:10.1038/msb4100012. PMC 1681463. PMID 16729043.
  • v
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  • 1u6t: Crystal structure of the human SH3 binding glutamic-rich protein like
    1u6t: Crystal structure of the human SH3 binding glutamic-rich protein like
  • 1wry: Solution structure of the SH3 domain-binding glutamic acid-rich-like protein
    1wry: Solution structure of the SH3 domain-binding glutamic acid-rich-like protein


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