Protein-coding gene in the species Homo sapiens
OR2T4 |
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Identifiers |
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Aliases | OR2T4, OR1-60, OR2T4Q, olfactory receptor family 2 subfamily T member 4 |
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External IDs | MGI: 3030058; HomoloGene: 133015; GeneCards: OR2T4; OMA:OR2T4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1q44 | Start | 248,361,665 bp[1] |
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End | 248,362,627 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11|11 B1.3 | Start | 58,456,682 bp[2] |
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End | 58,461,379 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - ganglionic eminence
- prefrontal cortex
- Brodmann area 9
- primary visual cortex
- substantia nigra
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| Top expressed in | - esophagus
- conceptus
- placenta
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | |
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ENSG00000196944 ENSG00000275617 ENSG00000274870 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 248.36 – 248.36 Mb | Chr 11: 58.46 – 58.46 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Olfactory receptor 2T4 is a protein that in humans is encoded by the OR2T4 gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
OR2T4 has known odorant ligands, many of which have a "floral", "soapy", or "waxy" character, similar to lily of the valley:
See also
References
- ^ a b c ENSG00000275617, ENSG00000274870 GRCh38: Ensembl release 89: ENSG00000196944, ENSG00000275617, ENSG00000274870 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059279 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4".
- ^ Yasi EA, Eisen SL, Wang H, Sugianto W, Minniefield AR, Hoover KA, Branham PJ, Peralta-Yahya P (2019). "Rapid Deorphanization of Human Olfactory Receptors in Yeast". Biochemistry. 58 (16): 2160–2166. doi:10.1021/acs.biochem.8b01208. PMC 6482435. PMID 30977365.
Further reading
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 2 | |
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Family 3 | |
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Family 4 | |
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Family 5 | |
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Family 6 | |
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Family 7 | |
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Family 8 | |
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Family 9 | |
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Family 10 | |
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Family 11 | |
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Family 12 | |
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Family 13 | |
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