Protein-coding gene in the species Homo sapiens
OR10R2 |
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Identifiers |
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Aliases | OR10R2, OR1-8, OR10R2Q, olfactory receptor family 10 subfamily R member 2 |
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External IDs | HomoloGene: 121586; GeneCards: OR10R2; OMA:OR10R2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1q23.1 | Start | 158,472,220 bp[1] |
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End | 158,480,936 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - organ system
- thyroid gland
- blood
- multicellular organism
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| | More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - G protein-coupled receptor activity
- olfactory receptor activity
- transmembrane signaling receptor activity
- signal transducer activity
| Cellular component | - integral component of membrane
- plasma membrane
- membrane
| Biological process | - sensory perception of smell
- detection of chemical stimulus involved in sensory perception of smell
- detection of chemical stimulus involved in sensory perception
- signal transduction
- response to stimulus
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 158.47 – 158.48 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Olfactory receptor 10R2 is a protein that in humans is encoded by the OR10R2 gene.[3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198965 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR10R2 olfactory receptor, family 10, subfamily R, member 2".
Further reading
- Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 52 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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Family 2 | |
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Family 3 | |
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Family 4 | |
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Family 5 | |
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Family 6 | |
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Family 7 | |
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Family 8 | |
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Family 10 | |
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Family 11 | |
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Family 12 | |
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Family 13 | |
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