Protein-coding gene in the species Homo sapiens
OR2T11 |
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Identifiers |
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Aliases | OR2T11, OR2T11Q, olfactory receptor family 2 subfamily T member 11 (gene/pseudogene), olfactory receptor family 2 subfamily T member 11 |
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External IDs | HomoloGene: 84585; GeneCards: OR2T11; OMA:OR2T11 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1q44 | Start | 248,623,557 bp[1] |
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End | 248,635,091 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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| | More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - signal transducer activity
- olfactory receptor activity
- G protein-coupled receptor activity
| Cellular component | - plasma membrane
- membrane
- integral component of membrane
| Biological process | - sensory perception of smell
- signal transduction
- response to stimulus
- detection of chemical stimulus involved in sensory perception of smell
- G protein-coupled receptor signaling pathway
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 248.62 – 248.64 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Olfactory receptor 2T11 is a protein that in humans is encoded by the OR2T11 gene.[3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
Ligands
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000279301 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11".
- ^ a b c d Li, S.; et al. (2016). "Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols". J. Am. Chem. Soc. 138 (40): 13281–13288. doi:10.1021/jacs.6b06983. PMID 27659093.
Further reading
- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Class I (fish-like receptors) | Family 51 | |
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Family 56 | |
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Class II (tetrapod specific receptors) | Family 1 | |
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