Faktor licenciranja DNK replikacije MCM5

edit
Minichromosome maintenance complex component 5
Identifikatori
SimboliMCM5; CDC46; P1-CDC46
Vanjski IDOMIM: 602696 MGI: 103197 HomoloGene: 4904 GeneCards: MCM5 Gene
EC broj3.6.4.12
Ontologija gena
Molekulska funkcija • DNK vezivanje
• aktivnost DNK helikaze
• proteinsko vezivanje
Ćelijska komponenta • nukleus
• nukleoplazma
• nukleolus
Biološki proces • G1/S tranzicija mitotičkog ćelijskog ciklusa
• mitotički ćelijski ciklus
• DNK replikacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez417417218
EnsemblENSG00000100297ENSMUSG00000005410
UniProtP33992P49718
Ref. Sekv. (iRNK)NM_006739NM_008566
Ref. Sekv. (protein)NP_006730NP_032592
Lokacija (UCSC)Chr 22:
35.8 - 35.82 Mb		Chr 8:
75.11 - 75.13 Mb
PubMed pretraga[1][2]

Faktor licenciranja DNK replikacije MCM5 je protein koji je kod ljudi kodiran MCM5 genom.[1][2][3]

Protein kodiran ovim genom je strukturno veoma slian CDC46 proteinu iz S. cerevisiae, proteinu koji učestvuje u inicijaciji DNK replikacije. Ovaj protein je član MCM familije proteina koji vezuju hromatin. On može da formira interakcije sa najmanje dva druga člana ove familije. Ovaj protein je u većoj meri izražen tokom tranzicije iz G0 faze u G1/S fazu ćelijskog ciklusa, i smatra se da aktivno učestvuje u regulaciji ćelijskog ciklusa.[3]

Vidi još

Interakcije

MCM5 formira interakcije sa ORC2L,[4] MCM7,[4][5][6] STAT1,[6][7] MCM2,[4][6] CDC7,[4] MCM3[4][6] i ORC6L.[4]

Reference

  1. ↑ Paul R, Hu B, Musahl C, Hameister H, Knippers R (Sep 1996). „Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5”. Cytogenet Cell Genet 73 (4): 317–21. DOI:10.1159/000134366. PMID 8751386. 
  2. ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). „The DNA sequence of human chromosome 22”. Nature 402 (6761): 489–95. DOI:10.1038/990031. PMID 10591208. 
  3. ↑ 3,0 3,1 „Entrez Gene: MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)”. 
  4. ↑ 4,0 4,1 4,2 4,3 4,4 4,5 Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. (England) 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  5. ↑ Fujita, M; Kiyono T; Hayashi Y; Ishibashi M (Apr 1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. (UNITED STATES) 272 (16): 10928–35. DOI:10.1074/jbc.272.16.10928. ISSN 0021-9258. PMID 9099751. 
  6. ↑ 6,0 6,1 6,2 6,3 DaFonseca, C J; Shu F; Zhang J J (Mar 2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (6): 3034–9. DOI:10.1073/pnas.061487598. ISSN 0027-8424. PMC 30602. PMID 11248027. 
  7. ↑ Zhang, J J; Zhao Y; Chait B T; Lathem W W; Ritzi M; Knippers R; Darnell J E (Dec 1998). „Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation”. EMBO J. (ENGLAND) 17 (23): 6963–71. DOI:10.1093/emboj/17.23.6963. ISSN 0261-4189. PMC 1171044. PMID 9843502. 

Literatura

  • Burkhart R, Schulte D, Hu D, et al. (1995). „Interactions of human nuclear proteins P1Mcm3 and P1Cdc46.”. Eur. J. Biochem. 228 (2): 431–8. DOI:10.1111/j.1432-1033.1995.tb20281.x. PMID 7705359. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Hu B, Burkhart R, Schulte D, et al. (1994). „The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins”. Nucleic Acids Res. 21 (23): 5289–93. DOI:10.1093/nar/21.23.5289-a. PMC 310560. PMID 8265339. 
  • Ishimi Y, Ichinose S, Omori A, et al. (1996). „Binding of human minichromosome maintenance proteins with histone H3”. J. Biol. Chem. 271 (39): 24115–22. DOI:10.1074/jbc.271.39.24115. PMID 8798650. 
  • Fujita M, Kiyono T, Hayashi Y, Ishibashi M (1997). „In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP”. J. Biol. Chem. 272 (16): 10928–35. DOI:10.1074/jbc.272.16.10928. PMID 9099751. 
  • Tsuruga H, Yabuta N, Hashizume K, et al. (1997). „Expression, nuclear localization and interactions of human MCM/P1 proteins”. Biochem. Biophys. Res. Commun. 236 (1): 118–25. DOI:10.1006/bbrc.1997.6865. PMID 9223437. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Zhang JJ, Zhao Y, Chait BT, et al. (1999). „Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation”. EMBO J. 17 (23): 6963–71. DOI:10.1093/emboj/17.23.6963. PMC 1171044. PMID 9843502. 
  • Ohtani K, Iwanaga R, Nakamura M, et al. (1999). „Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F”. Oncogene 18 (14): 2299–309. DOI:10.1038/sj.onc.1202544. PMID 10327050. 
  • DaFonseca CJ, Shu F, Zhang JJ (2001). „Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma”. Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. DOI:10.1073/pnas.061487598. PMC 30602. PMID 11248027. 
  • Going JJ, Keith WN, Neilson L, et al. (2002). „Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa”. Gut 50 (3): 373–7. DOI:10.1136/gut.50.3.373. PMC 1773132. PMID 11839717. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111–28. DOI:10.1016/S0022-2836(03)00079-2. PMID 12614612. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). „A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway”. Nat. Cell Biol. 6 (2): 97–105. DOI:10.1038/ncb1086. PMID 14743216. 
  • Ramachandran N, Hainsworth E, Bhullar B, et al. (2004). „Self-assembling protein microarrays”. Science 305 (5680): 86–90. DOI:10.1126/science.1097639. PMID 15232106. 
  • Yu Z, Feng D, Liang C (2004). „Pairwise interactions of the six human MCM protein subunits”. J. Mol. Biol. 340 (5): 1197–206. DOI:10.1016/j.jmb.2004.05.024. PMID 15236977. 
  • Jin J, Smith FD, Stark C, et al. (2004). „Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization”. Curr. Biol. 14 (16): 1436–50. DOI:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • p
  • r
  • u
Separacija
i inicijacija
Prokariotska
(inicijacija)
Eukariotska
(priprema u
G1 fazi)
Oba
Replikacija
Prokariotska
(elongacija)
Eukariotska
(sinteza u
S fazi)
Oba
Kretanje: Procesivnost • DNK ligaza
Terminacija
B bsyn: dnk (repl, cycl, reco, repr) • tscr (fact, tcrg, nucl, rnat, rept, ptts) • tltn (risu, pttl, nexn) • dnab, rnab/runp • stru (domn, 1°, 2°, 3°, 4°)