TXNIP

Mammalian protein found in Homo sapiens

TXNIP

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4GEI, 4GEJ, 4GFX, 4LL1, 4LL4, 4ROF, 4ROJ, 5CQ2, 5DF6, 5DWS, 5DZD

Identifiers

Aliases

TXNIP, thioredoxin interacting protein, EST01027, HHCPA78, THIF, VDUP1, ARRDC6

External IDs

OMIM: 606599; MGI: 1889549; HomoloGene: 38186; GeneCards: TXNIP; OMA:TXNIP - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.1	Start	145,992,435 bp^[1]
Band	1q21.1	End	145,996,579 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3 F2.1\|3 41.93 cM	Start	96,465,273 bp^[2]
Band	3 F2.1\|3 41.93 cM	End	96,469,199 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lung

gastric mucosa

cardia

pericardium

skin of hip

renal medulla

deltoid muscle

canal of the cervix

nipple

glutes

Top expressed in

right lung

submandibular gland

right lung lobe

masseter muscle

left lung

muscle of thigh

brown adipose tissue

left lung lobe

secondary oocyte

gastrula

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	enzyme inhibitor activity protein binding ubiquitin protein ligase binding
Cellular component	cytoplasm cytosol mitochondrial intermembrane space nucleus
Biological process	cellular response to tumor cell response to estradiol negative regulation of catalytic activity regulation of transcription, DNA-templated protein import into nucleus response to progesterone response to mechanical stimulus negative regulation of transcription by RNA polymerase II response to glucose response to oxidative stress transcription, DNA-templated keratinocyte differentiation response to calcium ion negative regulation of cell division regulation of cell population proliferation positive regulation of apoptotic process cell cycle platelet-derived growth factor receptor signaling pathway response to hydrogen peroxide signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10628


56338

Ensembl


ENSG00000265972


ENSMUSG00000038393

UniProt


Q9H3M7


Q8BG60

RefSeq (mRNA)


NM_006472 NM_001313972


NM_001009935 NM_023719

RefSeq (protein)


NP_001300901 NP_006463


NP_001009935 NP_076208

Location (UCSC)

Chr 1: 145.99 – 146 Mb

Chr 3: 96.47 – 96.47 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.^[5]^[6]

Interactions

TXNIP has been shown to interact with Thioredoxin^[7] and ZBTB32.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000265972 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038393 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.
^ "Entrez Gene: TXNIP thioredoxin interacting protein".
^ Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
^ Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.

Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
Ludwig DL, Kotanides H, Le T, Chavkin D, Bohlen P, Witte L (May 2001). "Cloning, genetic characterization, and chromosomal mapping of the mouse VDUP1 gene". Gene. 269 (1–2): 103–12. doi:10.1016/S0378-1119(01)00455-3. PMID 11376942.
Bodnar JS, Chatterjee A, Castellani LW, Ross DA, Ohmen J, Cavalcoli J, Wu C, Dains KM, Catanese J, Chu M, Sheth SS, Charugundla K, Demant P, West DB, de Jong P, Lusis AJ (Jan 2002). "Positional cloning of the combined hyperlipidemia gene Hyplip1". Nature Genetics. 30 (1): 110–6. doi:10.1038/ng811. PMC 2846781. PMID 11753387.
Joguchi A, Otsuka I, Minagawa S, Suzuki T, Fujii M, Ayusawa D (Apr 2002). "Overexpression of VDUP1 mRNA sensitizes HeLa cells to paraquat". Biochemical and Biophysical Research Communications. 293 (1): 293–7. doi:10.1016/S0006-291X(02)00208-5. PMID 12054598.
Butler LM, Zhou X, Xu WS, Scher HI, Rifkind RA, Marks PA, Richon VM (Sep 2002). "The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin". Proceedings of the National Academy of Sciences of the United States of America. 99 (18): 11700–5. Bibcode:2002PNAS...9911700B. doi:10.1073/pnas.182372299. PMC 129332. PMID 12189205.
Schulze PC, De Keulenaer GW, Yoshioka J, Kassik KA, Lee RT (Oct 2002). "Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin". Circulation Research. 91 (8): 689–95. doi:10.1161/01.RES.0000037982.55074.F6. PMID 12386145.
Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.
Champliaud MF, Viel A, Baden HP (Oct 2003). "The expression of vitamin D-upregulated protein 1 in skin and its interaction with sciellin in cultured keratinocytes". The Journal of Investigative Dermatology. 121 (4): 781–5. doi:10.1046/j.1523-1747.2003.12539.x. PMID 14632196.
Kim KY, Shin SM, Kim JK, Paik SG, Yang Y, Choi I (Mar 2004). "Heat shock factor regulates VDUP1 gene expression". Biochemical and Biophysical Research Communications. 315 (2): 369–75. doi:10.1016/j.bbrc.2004.01.047. PMID 14766217.
Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT (Jul 2004). "Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein". The Journal of Biological Chemistry. 279 (29): 30369–74. doi:10.1074/jbc.M400549200. PMID 15128745.
Coon H, Singh N, Dunn D, Eckfeldt JH, Province MA, Hopkins PN, Weiss R, Hunt SC, Leppert MF (Jun 2004). "TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study". Atherosclerosis. 174 (2): 357–62. doi:10.1016/j.atherosclerosis.2004.02.004. PMID 15136067.
Nishinaka Y, Masutani H, Oka S, Matsuo Y, Yamaguchi Y, Nishio K, Ishii Y, Yodoi J (Sep 2004). "Importin alpha1 (Rch1) mediates nuclear translocation of thioredoxin-binding protein-2/vitamin D(3)-up-regulated protein 1". The Journal of Biological Chemistry. 279 (36): 37559–65. doi:10.1074/jbc.M405473200. PMID 15234975.
Aitken CJ, Hodge JM, Nishinaka Y, Vaughan T, Yodoi J, Day CJ, Morrison NA, Nicholson GC (Dec 2004). "Regulation of human osteoclast differentiation by thioredoxin binding protein-2 and redox-sensitive signaling". Journal of Bone and Mineral Research. 19 (12): 2057–64. doi:10.1359/JBMR.040913. PMID 15537450. S2CID 26600161.
Yamawaki H, Pan S, Lee RT, Berk BC (Mar 2005). "Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells". The Journal of Clinical Investigation. 115 (3): 733–8. doi:10.1172/JCI23001. PMC 546457. PMID 15696199.
Minn AH, Hafele C, Shalev A (May 2005). "Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis". Endocrinology. 146 (5): 2397–405. doi:10.1210/en.2004-1378. PMID 15705778.