Cleavage stimulation factor
Cleavage stimulatory factor or cleavage stimulation factor (CstF or CStF) is a heterotrimeric protein, made up of the proteins CSTF1 (55kDa), CSTF2 (64kDa) and CSTF3 (77kDa), totalling about 200 kDa. It is involved in the cleavage of the 3' signaling region from a newly synthesized pre-messenger RNA (mRNA) molecule. CstF is recruited by cleavage and polyadenylation specificity factor (CPSF) and assembles into a protein complex on the 3' end to promote the synthesis of a functional polyadenine tail, which results in a mature mRNA molecule ready to be exported from the cell nucleus to the cytosol for translation.
The amount of CstF in a cell is dependent on the phase of the cell cycle, increasing significantly during the transition from G0 phase to S phase in mouse fibroblast and human splenic B cells.[1]
Genes
References
- ^ Martincic, K.; Campbell, R.; Edwalds-Gilbert, G.; Souan, L.; Lotze, M. T.; Milcarek, C. (1998). "Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition". Proceedings of the National Academy of Sciences of the United States of America. 95 (19): 11095–11100. Bibcode:1998PNAS...9511095M. doi:10.1073/pnas.95.19.11095. PMC 21601. PMID 9736695.
Further reading
- Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004). Molecular Cell Biology. WH Freeman: New York, NY. 5th ed.
External links
- Cleavage+stimulation+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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- Butyrate response factor 1
- Fragile X mental retardation protein
- Rev
- hu paraneoplastic encephalomyelitis antigens
- mRNA cleavage and polyadenylation factors (Cleavage and polyadenylation specificity factor
- Cleavage stimulation factor)
- host factor 1 protein
- Aconitase (ACO1
- ACO2)
- nuclear factor 90 proteins (ILF2)
- Poly(A)-binding protein (PABPC1
- PABPC3
- PABPC4)
- polypyrimidine tract-binding protein
- ribonucleoprotein
- RNA cap-binding protein (Cap binding complex
- EIF4E
- EIF4G1)
- SMN complex proteins (SMN1
- SMN2
- DDX20)
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