CSTF2T

Protein-coding gene in the species Homo sapiens

CSTF2T

Identifiers

Aliases

CSTF2T, CstF-64T, cleavage stimulation factor subunit 2, tau variant, cleavage stimulation factor subunit 2 tau variant

External IDs

OMIM: 611968; MGI: 1932622; HomoloGene: 80230; GeneCards: CSTF2T; OMA:CSTF2T - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q21.1	Start	51,695,486 bp^[1]
Band	10q21.1	End	51,699,595 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 C1	Start	31,060,237 bp^[2]
Band	19\|19 C1	End	31,064,469 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

germinal epithelium

Epithelium of choroid plexus

parietal pleura

pons

islet of Langerhans

ganglionic eminence

corpus callosum

Descending thoracic aorta

subthalamic nucleus

Top expressed in

pineal gland

medial ganglionic eminence

olfactory tubercle

habenula

lateral septal nucleus

anterior amygdaloid area

subiculum

lobe of cerebellum

cerebellar vermis

median eminence

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding mRNA binding nucleic acid binding RNA binding
Cellular component	mRNA cleavage and polyadenylation specificity factor complex intracellular anatomical structure nucleus nucleoplasm
Biological process	mRNA processing pre-mRNA cleavage required for polyadenylation mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA 3'-end processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23283


83410

Ensembl


ENSG00000177613


ENSMUSG00000053536

UniProt


Q9H0L4


Q8C7E9

RefSeq (mRNA)


NM_015235


NM_031249

RefSeq (protein)


NP_056050


NP_112539

Location (UCSC)

Chr 10: 51.7 – 51.7 Mb

Chr 19: 31.06 – 31.06 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Cleavage stimulation factor 64 kDa subunit, tau variant is a protein that in humans is encoded by the CSTF2T gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177613 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053536 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dass B, McDaniel L, Schultz RA, Attaya E, MacDonald CC (Oct 2002). "The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein tauCstF-64, lacks introns and may be associated with male sterility". Genomics. 80 (5): 509–14. doi:10.1016/S0888-7543(02)96862-X. PMID 12408968.
^ Dass B, McMahon KW, Jenkins NA, Gilbert DJ, Copeland NG, MacDonald CC (May 2001). "The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice". J Biol Chem. 276 (11): 8044–50. doi:10.1074/jbc.M009091200. PMID 11113135.
^ "Entrez Gene: CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant".

External links

Human CSTF2T genome location and CSTF2T gene details page in the UCSC Genome Browser.

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PDB gallery

1p1t: NMR Structure of the N-terminal RRM domain of Cleavage stimulation factor 64 KDa subunit
2j8p: NMR STRUCTURE OF C-TERMINAL DOMAIN OF HUMAN CSTF-64