BRCA2 |
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已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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識別號 |
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别名 | BRCA2;, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes |
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外部ID | OMIM:600185 MGI:109337 HomoloGene:41 GeneCards:BRCA2 |
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相關疾病 |
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BRCA2 hereditary breast and ovarian cancer syndrome、Fanconi anemia complementation group D1、breast carcinoma、prostate carcinoma、cerebellar medulloblastoma、泌尿生殖肿瘤、卵巢腫瘤、hereditary breast ovarian cancer[1] |
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基因位置(小鼠) |
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| 染色体 | 小鼠5号染色体[3] |
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| 基因座 | 5 G3|5 89.52 cM | 起始 | 150,446,095 bp[3] |
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终止 | 150,493,794 bp[3] |
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RNA表达模式 |
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查阅更多表达数据 |
基因本體 |
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分子功能 | • DNA结合 • H4 histone acetyltransferase activity • H3 histone acetyltransferase activity • 蛋白酶結合 • histone acetyltransferase activity • 血浆蛋白结合 • gamma-tubulin binding • single-stranded DNA binding • protein C-terminus binding • 相同蛋白质结合
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細胞組分 | • 中心体 • BRCA2-MAGE-D1 complex • secretory granule • 核质 • 微管组织中心 • 细胞核 • 细胞骨架 • lateral element • 細胞質 • 细胞质基质 • 大分子复合体
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生物學過程 | • chordate embryonic development • 核苷酸切除修复 • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • DNA重组 • regulation of cytokinesis • replication fork protection • centrosome duplication • male meiosis I • negative regulation of mammary gland epithelial cell proliferation • positive regulation of mitotic cell cycle • chromosome organization • female gonad development • inner cell mass cell proliferation • positive regulation of transcription, DNA-templated • telomere maintenance via recombination • brain development • oocyte maturation • histone H3 acetylation • 精子发生 • intrinsic apoptotic signaling pathway in response to DNA damage • establishment of protein localization to telomere • histone H4 acetylation • cellular response to DNA damage stimulus • 細胞週期 • 細胞增殖 • response to gamma radiation • response to UV-C • response to X-ray • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • mitotic recombination-dependent replication fork processing • double-strand break repair via homologous recombination • DNA修復 • double-strand break repair • mitotic cytokinesis • 造血作用 • response to nutrient • meiotic DNA repair synthesis involved in reciprocal meiotic recombination • 乳腺发育 • homologous chromosome orientation involved in meiotic metaphase I plate congression • response to estradiol • multicellular organism growth • DNA synthesis involved in double-strand break repair via homologous recombination • meiotic recombination checkpoint signaling
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | | |
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蛋白序列 | | |
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基因位置(UCSC) | Chr 13: 32.32 – 32.4 Mb | Chr 5: 150.45 – 150.49 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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