PDGFB

Наявні структури

Пошук ортологів: PDBe RCSB

Список кодів PDB
1PDG, 3MJG, 4HQU, 4HQX, 4QCI

Ідентифікатори

Символи

PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B

Зовнішні ІД

OMIM: 190040 MGI: 97528 HomoloGene: 74303 GeneCards: PDGFB

Онтологія гена
Молекулярна функція	• protein homodimerization activity • protein heterodimerization activity • chemoattractant activity • platelet-derived growth factor receptor binding • platelet-derived growth factor binding • superoxide-generating NADPH oxidase activator activity • growth factor activity • identical protein binding • collagen binding • GO:0001948, GO:0016582 protein binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Клітинна компонента	• platelet alpha granule lumen • цитоплазма • extracellular region • Golgi membrane • basolateral plasma membrane • cell surface • endoplasmic reticulum lumen • мембрана • GO:0005578 Позаклітинна матриця • міжклітинний простір • Golgi lumen • collagen-containing extracellular matrix
Біологічний процес	• activation of protein kinase B activity • positive regulation of DNA biosynthetic process • positive regulation of chemotaxis • cellular response to growth factor stimulus • positive regulation of protein tyrosine kinase activity • peptidyl-tyrosine phosphorylation • positive regulation of cell division • heart development • positive regulation of glomerular filtration • positive regulation of mitotic nuclear division • positive regulation of MAP kinase activity • positive regulation of metanephric mesenchymal cell migration • positive regulation of hyaluronan biosynthetic process • MAPK cascade • protein phosphorylation • positive regulation of glomerular mesangial cell proliferation • cellular response to mycophenolic acid • positive regulation of fibroblast proliferation • activation of protein kinase activity • multicellular organism development • positive regulation of protein autophosphorylation • positive regulation of reactive oxygen species metabolic process • reactive oxygen species metabolic process • GO:0045996 negative regulation of transcription, DNA-templated • protein kinase C signaling • metanephric glomerular mesangial cell development • negative regulation of phosphatidylinositol biosynthetic process • response to wounding • positive regulation of phosphatidylinositol 3-kinase activity • cell chemotaxis • positive regulation of ERK1 and ERK2 cascade • platelet degranulation • positive regulation of cell population proliferation • positive regulation of DNA replication • GO:1901313 positive regulation of gene expression • embryonic placenta development • paracrine signaling • monocyte chemotaxis • positive regulation of endothelial cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of calcium ion import • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0035404 peptidyl-serine phosphorylation • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • positive regulation of blood vessel endothelial cell migration • кровотворення • positive regulation of cell migration • positive regulation of peptidyl-tyrosine phosphorylation • extracellular matrix organization • negative regulation of protein binding • positive regulation of MAPK cascade • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of platelet activation • phosphatidylinositol phosphate biosynthetic process • positive regulation of vascular associated smooth muscle cell migration • positive chemotaxis • negative regulation of vascular associated smooth muscle cell differentiation • interleukin-18-mediated signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of gene expression • positive regulation of smooth muscle cell migration • positive regulation of smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell dedifferentiation • platelet-derived growth factor receptor signaling pathway • positive regulation of vascular associated smooth muscle cell proliferation • negative regulation of platelet-derived growth factor receptor-beta signaling pathway • regulation of signaling receptor activity • positive regulation of protein kinase B signaling
Джерела:Amigo / QuickGO

Шаблон експресії

Більше даних

Ортологи

Види

Людина

Миша

Entrez


5155


18591

Ensembl


ENSG00000100311


ENSMUSG00000000489

UniProt


P01127


P31240

RefSeq (мРНК)


NM_033016 NM_002608


NM_011057

RefSeq (білок)


NP_002599 NP_148937


NP_035187

Локус (UCSC)

Хр. 22: 39.22 – 39.24 Mb

Хр. 15: 80 – 80.01 Mb

PubMed search

^[1]

^[2]

Вікідані

Див./Ред. для людей

Див./Ред. для мишей

PDGFB (англ. Platelet derived growth factor subunit B) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 22-ї хромосоми.^[3] Довжина поліпептидного ланцюга білка становить 241 амінокислот, а молекулярна маса — 27 283^[4].

Послідовність амінокислот

10	20	30	40	50
MNRCWALFLS	LCCYLRLVSA	EGDPIPEELY	EMLSDHSIRS	FDDLQRLLHG
DPGEEDGAEL	DLNMTRSHSG	GELESLARGR	RSLGSLTIAE	PAMIAECKTR
TEVFEISRRL	IDRTNANFLV	WPPCVEVQRC	SGCCNNRNVQ	CRPTQVQLRP
VQVRKIEIVR	KKPIFKKATV	TLEDHLACKC	ETVAAARPVT	RSPGGSQEQR
AKTPQTRVTI	RTVRVRRPPK	GKHRKFKHTH	DKTALKETLG	A

A: Аланін
C: Цистеїн
D: Аспарагінова кислота
E: Глутамінова кислота
F: Фенілаланін
G: Гліцин
H: Гістидин
I: Ізолейцин
K: Лізин
L: Лейцин
M: Метіонін
N: Аспарагін
P: Пролін
Q: Глутамін
R: Аргінін
S: Серин
T: Треонін
V: Валін
W: Триптофан

Y: Тирозин

Кодований геном білок за функціями належить до факторів росту, мітогенів, білків розвитку. Секретований назовні.

Література

Collins T., Ginsburg D., Boss J.M., Orkin S.H., Pober J.S. (1985). Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Nature. 316: 748—750. PMID 4033772 DOI:10.1038/316748a0
Ratner L., Josephs S.F., Jarrett R., Reitz M.S., Wong-Staal F. (1985). Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor. Nucleic Acids Res. 13: 5007—5018. PMID 2991848 DOI:10.1093/nar/13.14.5007
Rao C.D., Igarashi H., Chiu I.-M., Robbins K.C., Aaronson S.A. (1986). Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit. Proc. Natl. Acad. Sci. U.S.A. 83: 2392—2396. PMID 3517869 DOI:10.1073/pnas.83.8.2392
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Dirks R.P.H., Onnekink C., Jansen H.J., de Jong A., Bloemers H.P.J. (1995). A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein. Nucleic Acids Res. 23: 2815—2822. PMID 7659502 DOI:10.1093/nar/23.15.2815
Weich H.A., Sebald W., Schairer H.U., Hoppe J. (1986). The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain. FEBS Lett. 198: 344—348. PMID 3456904 DOI:10.1016/0014-5793(86)80433-1

Примітки

↑ Human PubMed Reference:.
↑ Mouse PubMed Reference:.
↑ HUGO Gene Nomenclature Commitee, HGNC:8800 (англ.) . Процитовано 12 вересня 2017.{{cite web}}: Обслуговування CS1: Сторінки з параметром url-status, але без параметра archive-url (посилання)
↑ UniProt, P01127 (англ.) . Архів оригіналу за 25 вересня 2017. Процитовано 12 вересня 2017.