| FBXW7 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 2OVP, 2OVQ, 2OVR, 5IBK | | |
| Ідентифікатори |
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| Символи | FBXW7, AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4, F-box and WD repeat domain containing 7 |
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| Зовнішні ІД | OMIM: 606278 HomoloGene: 117451 GeneCards: FBXW7 |
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| Онтологія гена |
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| Молекулярна функція | • protein-macromolecule adaptor activity
• GO:0001948, GO:0016582 protein binding
• ubiquitin-protein transferase activator activity
• identical protein binding
• ubiquitin protein ligase binding
• cyclin binding
• phosphothreonine residue binding
• GO:0050372 ubiquitin-protein transferase activity
• ubiquitin binding
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| Клітинна компонента | • цитоплазма
• Parkin-FBXW7-Cul1 ubiquitin ligase complex
• SCF ubiquitin ligase complex
• нуклеоплазма
• ядерце
• клітинне ядро
• гіалоплазма
• мітохондрія
• ендоплазматичний ретикулум
• комплекс Ґольджі
• perinuclear region of cytoplasm
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| Біологічний процес | • positive regulation of epidermal growth factor-activated receptor activity
• positive regulation of protein targeting to mitochondrion
• negative regulation of SREBP signaling pathway
• cellular response to UV
• negative regulation of triglyceride biosynthetic process
• protein stabilization
• negative regulation of hepatocyte proliferation
• sister chromatid cohesion
• cellular response to DNA damage stimulus
• regulation of protein localization
• positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
• vasculature development
• regulation of autophagy of mitochondrion
• negative regulation of DNA endoreduplication
• positive regulation of ubiquitin-protein transferase activity
• positive regulation of ubiquitin-dependent protein catabolic process
• Убіквітин-залежний протеоліз
• lipid homeostasis
• positive regulation of ERK1 and ERK2 cascade
• regulation of cell cycle G1/S phase transition
• regulation of lipid storage
• GO:0022415 viral process
• positive regulation of proteasomal protein catabolic process
• positive regulation of protein ubiquitination
• negative regulation of Notch signaling pathway
• protein polyubiquitination
• посттрансляційна модифікація
• negative regulation of osteoclast development
• васкулогенез
• Сигнальний шлях Notch
• negative regulation of gene expression
• ubiquitin recycling
• lung development
• protein destabilization
• proteasome-mediated ubiquitin-dependent protein catabolic process
• regulation of cell migration involved in sprouting angiogenesis
• negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
• regulation of circadian rhythm
• ритмічний процес
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001013415
NM_001257069
NM_018315
NM_033632
NM_001349798 |
| XM_002729089
XM_003749311
XM_006232555
XM_017596140
XM_017596144
| XM_017596146
XM_017596147
XM_017596148
XM_017596149 |
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| RefSeq (білок) | | NP_001013433
NP_001243998
NP_060785
NP_361014
NP_001336727 |
| XP_003749359
XP_006232617
XP_038959666
XP_038959667
XP_038959668
| XP_038959669
XP_038959670
XP_038959671
XP_038959672 |
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| Локус (UCSC) | Хр. 4: 152.32 – 152.54 Mb | н/д |
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| PubMed search | [1] | [2] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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