Аполіпопротеїн E |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B | | |
Ідентифікатори |
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Символи | APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4 |
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Зовнішні ІД | OMIM: 107741 MGI: 88057 HomoloGene: 30951 GeneCards: APOE |
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Пов'язані генетичні захворювання |
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хвороба Альцгеймера, мікроцефалія, Alzheimer disease 2, sea-blue histiocyte syndrome, lipoprotein glomerulopathy, ішемічна хвороба серця, familial dysbetalipoproteinemia[1] |
Онтологія гена |
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Молекулярна функція | • heparin binding • very-low-density lipoprotein particle receptor binding • low-density lipoprotein particle receptor binding • lipoprotein particle binding • phosphatidylcholine-sterol O-acyltransferase activator activity • phospholipid binding • GO:0017127 cholesterol transfer activity • protein homodimerization activity • amyloid-beta binding • GO:0001948, GO:0016582 protein binding • tau protein binding • metal chelating activity • lipid transporter activity • cholesterol binding • antioxidant activity • identical protein binding • lipid binding |
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Клітинна компонента | • цитоплазма • мембрана • chylomicron • extracellular region • клітинне ядро • extracellular vesicle • endocytic vesicle lumen • very-low-density lipoprotein particle • extracellular fluid • ендоплазматичний ретикулум • екзосома • комплекс Ґольджі • blood microparticle • GO:0005578 Позаклітинна матриця • клітинна мембрана • neuronal cell body • early endosome • low-density lipoprotein particle • дендрит (нейробіологія) • high-density lipoprotein particle • intermediate-density lipoprotein particle |
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Біологічний процес | • GO:1904089 negative regulation of neuron apoptotic process • response to dietary excess • negative regulation of lipid transport across blood-brain barrier • lipid transport • positive regulation of lipid biosynthetic process • regulation of axon extension • positive regulation of postsynaptic membrane organization • positive regulation of cholesterol esterification • phospholipid efflux • cholesterol catabolic process • positive regulation of dendritic spine development • рецептор-опосередкований ендоцитоз • retinoid metabolic process • positive regulation of amyloid-beta formation • lipid homeostasis • lipoprotein biosynthetic process • cholesterol homeostasis • negative regulation of inflammatory response • triglyceride metabolic process • negative regulation of canonical Wnt signaling pathway • negative regulation of dendritic spine maintenance • negative regulation of blood vessel endothelial cell migration • NMDA glutamate receptor clustering • GO:0001315 response to reactive oxygen species • negative regulation of blood coagulation • GO:0001306 response to oxidative stress • positive regulation of nitric-oxide synthase activity • negative regulation of phospholipid efflux • positive regulation of cholesterol efflux • negative regulation of MAP kinase activity • artery morphogenesis • very-low-density lipoprotein particle remodeling • regulation of neuronal synaptic plasticity • negative regulation of dendritic spine development • negative regulation of cholesterol biosynthetic process • positive regulation of dendritic spine maintenance • positive regulation of phospholipid efflux • negative regulation of presynaptic membrane organization • negative regulation of neuron death • high-density lipoprotein particle clearance • long-chain fatty acid transport • lipoprotein metabolic process • regulation of tau-protein kinase activity • G protein-coupled receptor signaling pathway • chylomicron remnant clearance • cellular calcium ion homeostasis • cholesterol metabolic process • very-low-density lipoprotein particle clearance • virion assembly • negative regulation of lipid biosynthetic process • cGMP-mediated signaling • triglyceride catabolic process • positive regulation of presynaptic membrane organization • positive regulation of neurofibrillary tangle assembly • AMPA glutamate receptor clustering • positive regulation of low-density lipoprotein particle receptor catabolic process • positive regulation of lipid transport across blood-brain barrier • fatty acid homeostasis • nitric oxide mediated signal transduction • GO:0015915 транспорт • cholesterol efflux • регуляція експресії генів • negative regulation of cholesterol efflux • regulation of amyloid-beta clearance • neuron projection regeneration • negative regulation of postsynaptic membrane organization • steroid metabolic process • regulation of Cdc42 protein signal transduction • lipid metabolism • negative regulation of amyloid-beta formation • positive regulation of membrane protein ectodomain proteolysis • вазодилатація • intracellular transport • synaptic transmission, cholinergic • positive regulation of neuron death • high-density lipoprotein particle assembly • protein import • high-density lipoprotein particle remodeling • negative regulation of endothelial cell proliferation • maintenance of location in cell • negative regulation of platelet activation • low-density lipoprotein particle remodeling • positive regulation by host of viral process • cytoskeleton organization • regulation of neuron death • reverse cholesterol transport • lipoprotein catabolic process • triglyceride homeostasis • cellular oxidant detoxification • lipid transport involved in lipid storage |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001302691 NM_000041 NM_001302688 NM_001302689 NM_001302690 |
| | NM_009696 NM_001305819 NM_001305843 NM_001305844 |
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RefSeq (білок) | | NP_000032 NP_001289617 NP_001289618 NP_001289619 NP_001289620 |
| | NP_001292748 NP_001292772 NP_001292773 NP_033826 |
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Локус (UCSC) | Хр. 19: 44.91 – 44.91 Mb | Хр. 7: 19.43 – 19.43 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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