XRCC4

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XRCC4

PDB prikaz baziran na 1fu1.

Dostupne strukture

1fu1

Identifikatori

Simboli

XRCC4;

Vanjski ID

OMIM: 194363 MGI: 1333799 HomoloGene: 2555 GeneCards: XRCC4 Gene

Ontologija gena
Molekularna funkcija	• DNK vezivanje • proteinsko vezivanje • proteinsko C-terminusno vezivanje • aktivnost ligaze
Celularna komponenta	• kondenzovani hromozom • nukleus • nukleoplazma • citozol • DNK zavisna proteinska kinaza - DNK ligaza 4 kompleks • DNK ligaza IV kompleks
Biološki proces	• in utero embrionski razvoj • pro-B ćelijska diferencijacija • popravka DNK • popravka dvolančanih prekida • popravka dvolančanih prekida nehomolognim spajanjem krajeva

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

7518

108138

Ensembl

ENSG00000152422

ENSMUSG00000021615

UniProt

Q13426

Q924T3

RefSeq (mRNA)

NM_003401.3

NM_028012.4

RefSeq (protein)

NP_003392.1

NP_082288.1

Lokacija (UCSC)

Chr 5:
82.37 - 82.65 Mb

Chr 13:
89.91 - 90.23 Mb

PubMed pretraga

[1]

[2]

Protein popravke DNK XRCC4 je kod ljudi kodiran XRCC4 genom.^[1]^[2]^[3]

Interakcije

XRCC4 formira interakcije sa LIG4^[4]^[5] i XLF protein.^[4]

Reference

↑ Giaccia AJ, Denko N, MacLaren R, Mirman D, Waldren C, Hart I, Stamato TD (September 1990). „Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant”. Am J Hum Genet 47 (3): 459–69. PMC 1683886. PMID 1697445.
↑ Otevrel T, Stamato TD (October 1995). „Regional localization of the XRCC4 human radiation repair gene”. Genomics 27 (1): 211–4. DOI:10.1006/geno.1995.1029. PMID 7665175.
↑ „Entrez Gene: XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4”.
↑ ^4,0 ^4,1 Deshpande, Rajashree A; Wilson Thomas E (October 2007). „Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4”. DNA Repair (Amst.) (Netherlands) 6 (10): 1507–16. DOI:10.1016/j.dnarep.2007.04.014. ISSN 1568-7864. PMC 2064958. PMID 17567543.
↑ Sibanda, B L; Critchlow S E, Begun J, Pei X Y, Jackson S P, Blundell T L, Pellegrini L (December 2001). „Crystal structure of an Xrcc4-DNA ligase IV complex”. Nat. Struct. Biol. (United States) 8 (12): 1015–9. DOI:10.1038/nsb725. ISSN 1072-8368. PMID 11702069.

Literatura

Lieber MR (1999). „The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes.”. Genes Cells 4 (2): 77–85. DOI:10.1046/j.1365-2443.1999.00245.x. PMID 10320474.
Li Z, Otevrel T, Gao Y, et al. (1996). „The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.”. Cell 83 (7): 1079–89. DOI:10.1016/0092-8674(95)90135-3. PMID 8548796.
Grawunder U, Wilm M, Wu X, et al. (1997). „Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.”. Nature 388 (6641): 492–5. DOI:10.1038/41358. PMID 9242410.
Critchlow SE, Bowater RP, Jackson SP (1997). „Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.”. Curr. Biol. 7 (8): 588–98. DOI:10.1016/S0960-9822(06)00258-2. PMID 9259561.
Mizuta R, Cheng HL, Gao Y, Alt FW (1998). „Molecular genetic characterization of XRCC4 function.”. Int. Immunol. 9 (10): 1607–13. DOI:10.1093/intimm/9.10.1607. PMID 9352367.
Leber R, Wise TW, Mizuta R, Meek K (1998). „The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase.”. J. Biol. Chem. 273 (3): 1794–801. DOI:10.1074/jbc.273.3.1794. PMID 9430729.
Gao Y, Sun Y, Frank KM, et al. (1999). „A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.”. Cell 95 (7): 891–902. DOI:10.1016/S0092-8674(00)81714-6. PMID 9875844.
Modesti M, Hesse JE, Gellert M (1999). „DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.”. EMBO J. 18 (7): 2008–18. DOI:10.1093/emboj/18.7.2008. PMC 1171285. PMID 10202163.
Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA (2000). „Ku recruits the XRCC4-ligase IV complex to DNA ends.”. Mol. Cell. Biol. 20 (9): 2996–3003. DOI:10.1128/MCB.20.9.2996-3003.2000. PMC 85565. PMID 10757784.
Gao Y, Ferguson DO, Xie W, et al. (2000). „Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.”. Nature 404 (6780): 897–900. DOI:10.1038/35009138. PMID 10786799.
Chen L, Trujillo K, Sung P, Tomkinson AE (2000). „Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.”. J. Biol. Chem. 275 (34): 26196–205. DOI:10.1074/jbc.M000491200. PMID 10854421.
Lee KJ, Huang J, Takeda Y, Dynan WS (2000). „DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system.”. J. Biol. Chem. 275 (44): 34787–96. DOI:10.1074/jbc.M004011200. PMID 10945980.
Ford BN, Ruttan CC, Kyle VL, et al. (2000). „Identification of single nucleotide polymorphisms in human DNA repair genes.”. Carcinogenesis 21 (11): 1977–81. DOI:10.1093/carcin/21.11.1977. PMID 11062157.
Sibanda BL, Critchlow SE, Begun J, et al. (2002). „Crystal structure of an Xrcc4-DNA ligase IV complex.”. Nat. Struct. Biol. 8 (12): 1015–9. DOI:10.1038/nsb725. PMID 11702069.
Lee KJ, Dong X, Wang J, et al. (2002). „Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region.”. J. Immunol. 169 (6): 3413–21. PMID 12218164.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hsu HL, Yannone SM, Chen DJ (2003). „Defining interactions between DNA-PK and ligase IV/XRCC4.”. DNA Repair (Amst.) 1 (3): 225–35. DOI:10.1016/S1568-7864(01)00018-0. PMID 12509254.