Tirozin-tRNK ligaza
| Tirozin-tRNK ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.1.1.1 | ||||||||
| CAS broj | 9023-45-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Tirozin-tRNK ligaza (EC 6.1.1.1) je enzim sa sistematskim imenom L-tirozin:tRNKTir ligaza (formira AMP).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + L-tirozin + tRNKTyr AMP + difosfat + L-tirozil-tRNKTyr
Reference
- ↑ Allen, E.H., Glassman, E. and Schweet, R.S. (1960). „Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes”. J. Biol. Chem. 235: 1061-1067. PMID 13792726.
- ↑ Cowles, J.R. and Key, J.L. (1972). „Demonstration of two tyrosyl-tRNA synthetases of pea roots”. Biochim. Biophys. Acta 281: 33-44. PMID 4563531.
- ↑ Holley, R.W., Brunngraber, E.F., Saad, F. and Williams, H.H. (1961). „Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of potassium ions on the activity of the tyrosine enzyme”. J. Biol. Chem. 236: 197-199. PMID 13715350.
- ↑ Schweet, R.S. and Allen, E.H. (1958). „Purification and properties of tyrosine-activating enzyme of hog pancreas”. J. Biol. Chem. 233: 1104-1108. PMID 13598741.
- ↑ Brick, P., Bhat, T.N. and Blow, D.M. (1989). „Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate”. J. Mol. Biol. 208: 83-98. PMID 2504923.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Tyrosine---tRNA+ligase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
