Receptor retinoinske kiseline gama

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Receptor retinoinske kiseline, gama

PDB slika je bazirana na 3lbd.

Dostupne strukture

1dsz, 1exa, 1exx, 1fcx, 1fcy, 1fcz, 1fd0, 1hra, 2lbd, 3lbd, 4lbd

Identifikatori

Simboli

RARG; NR1B3; RARC

Vanjski ID

OMIM: 180190 MGI: 97858 HomoloGene: 20263 GeneCards: RARG Gene

Ontologija gena
Molekulska funkcija	• aktivnost transkripcionog faktora • aktivnost steroidnog hormonskog receptora • aktivnost receptora retinoinske kiseline • vezivanje za proteine • vezivanje jona cinka • sekvenca-specifično DNK vezivanje • vezivanje metalnog jona
Ćelijska komponenta	• nukleus • kompleks transkripcionog faktora
Biološki proces	• transkripcija • regulacija transkripcije, DNK-zavisna • razvoj multićelijskih organizama • pozitivna regulacija apoptoze • pozitivna regulacija transkripcije od promotora RNK polimeraze II • morfogeneza embrionskog oka

Ortolozi

Vrsta

Čovek

Miš

Entrez

5916

19411

Ensembl

n/a

ENSMUSG00000001288

UniProt

n/a

Q3UG86

Ref. Sekv. (iRNK)

XM_940838

NM_001042727

Ref. Sekv. (protein)

XP_945931

NP_001036192

Lokacija (UCSC)

n/a

Chr 15:
102.06 - 102.09 Mb

PubMed pretraga

[1]

[2]

Receptor retinoinske kiseline gama (RAR-gama), isto poznat kao NR1B3 (nuklearni receptor potfamilije 1, grupa B, član 3) je nuklearni receptor kodiran genom RARG.^[1]

Interakcije

Pokazano je za receptor retinoinske kiseline gama da može da formnira interakciju sa nuklearnim receptorom korepresorom 1.^[2]

Reference

↑ „Entrez Gene: RARG retinoic acid receptor, gamma”.
↑ Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (May 1999). „Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein”. J. Biol. Chem. (UNITED STATES) 274 (22): 15901–7. ISSN 0021-9258. PMID 10336495.

Literatura

Leid M, Kastner P, Lyons R, et al. (1992). „Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.”. Cell 68 (2): 377–95. DOI:10.1016/0092-8674(92)90478-U. PMID 1310259.
Vollberg TM, Nervi C, George MD, et al. (1992). „Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation.”. Mol. Endocrinol. 6 (5): 667–76. DOI:10.1210/me.6.5.667. PMID 1318502.
Lehmann JM, Zhang XK, Pfahl M (1992). „RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites.”. Mol. Cell. Biol. 12 (7): 2976–85. PMID 1320193.
Mattei MG, Rivière M, Krust A, et al. (1991). „Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.”. Genomics 10 (4): 1061–9. DOI:10.1016/0888-7543(91)90199-O. PMID 1655630.
Lehmann JM, Hoffmann B, Pfahl M (1991). „Genomic organization of the retinoic acid receptor gamma gene.”. Nucleic Acids Res. 19 (3): 573–8. DOI:10.1093/nar/19.3.573. PMID 1849262.
Kastner P, Krust A, Mendelsohn C, et al. (1990). „Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.”. Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2700–4. DOI:10.1073/pnas.87.7.2700. PMID 2157210.
Giguère V, Shago M, Zirngibl R, et al. (1990). „Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.”. Mol. Cell. Biol. 10 (5): 2335–40. PMID 2157970.
Ishikawa T, Umesono K, Mangelsdorf DJ, et al. (1990). „A functional retinoic acid receptor encoded by the gene on human chromosome 12.”. Mol. Endocrinol. 4 (6): 837–44. DOI:10.1210/mend-4-6-837. PMID 2172793.
Krust A, Kastner P, Petkovich M, et al. (1989). „A third human retinoic acid receptor, hRAR-gamma.”. Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5310–4. DOI:10.1073/pnas.86.14.5310. PMID 2546152.
Renaud JP, Rochel N, Ruff M, et al. (1996). „Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.”. Nature 378 (6558): 681–9. DOI:10.1038/378681a0. PMID 7501014.
Zhou L, Pang J, Munroe DG, Lau C (1993). „A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7.”. Nucleic Acids Res. 21 (10): 2520. DOI:10.1093/nar/21.10.2520. PMID 7685085.
Zitnik RJ, Kotloff RM, Latifpour J, et al. (1994). „Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts.”. J. Immunol. 152 (3): 1419–27. PMID 8301142.
Botling J, Castro DS, Oberg F, et al. (1997). „Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation.”. J. Biol. Chem. 272 (14): 9443–9. DOI:10.1074/jbc.272.14.9443. PMID 9083083.
Lømo J, Smeland EB, Ulven S, et al. (1998). „RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes.”. J. Cell. Physiol. 175 (1): 68–77. DOI:10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A. PMID 9491782.
Klaholz BP, Renaud JP, Mitschler A, et al. (1998). „Conformational adaptation of agonists to the human nuclear receptor RAR gamma.”. Nat. Struct. Biol. 5 (3): 199–202. DOI:10.1038/nsb0398-199. PMID 9501913.
Zhang ZP, Gambone CJ, Gabriel JL, et al. (1999). „Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma.”. J. Biol. Chem. 273 (51): 34016–21. DOI:10.1074/jbc.273.51.34016. PMID 9852056.
Yang C, Zhou D, Chen S (1999). „Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor.”. Cancer Res. 58 (24): 5695–700. PMID 9865725.
Nagpal S, Ghosn C, DiSepio D, et al. (1999). „Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor.”. J. Biol. Chem. 274 (32): 22563–8. DOI:10.1074/jbc.274.32.22563. PMID 10428834.
Egea PF, Mitschler A, Rochel N, et al. (2000). „Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid.”. EMBO J. 19 (11): 2592–601. DOI:10.1093/emboj/19.11.2592. PMID 10835357.
Boudjelal M, Voorhees JJ, Fisher GJ (2002). „Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells.”. Exp. Cell Res. 274 (1): 130–7. DOI:10.1006/excr.2001.5450. PMID 11855864.

Vidi još

Receptor retinoinske kiseline

PDB Galerija

1dsz: Struktura RXR/RAR DNK-vezujućeg domena heterodimera u kompleksu sa responsivnim elementom DR1 retinoinske kiseline

1exa: Enatiomer diskriminacija ilustrovana kristalnim strukturama ljudskog ligand-vezujućeg domena retinoinskog receptora gama: kompleks sa aktivnim R-enantiomerom BMS270394.

1exx: Enatiomer diskriminacija ilustrovana kristalnim strukturama ljudskog ligand-vezujućeg domena retinoinskog receptora gama: kompleks sa inaktivnim S-enantiomerom BMS270395.

1fcx: Isotipna selektivnost ljudskog retinoinskog receptora gama: kompleks sa RAR-gama-selektivnim retinoidom BMS184394

1fcy: Isotipna selektivnost ljudskog retinoinskog receptora gama: kompleks sa RAR-beta/gama-selektivnim retinoidom CD564

1fcz: Isotipna selektivnost ljudskog retinoinskog receptora gama: kompleks sa pan-agonist retinoidom BMS181156

1fd0: Isotipna selektivnost ljudskog retinoinskog receptora gama: kompleks sa RAR-gama-selektini retinoid SR11254

1hra: Rešenje strukture DNK vezujućeg domena ljudskog retinoinskog receptora beta

2lbd: Ligand vezujući domen ljudskog retinoinskog receptora gama vezanog za sve-trans retinoinsku kiselinu

3lbd: Ligand vezujući domen ljudskog retinoinskog receptora gama vezanog za 9-cis retinoinsku kiselinu

4lbd: Ligand vezujući domen ljudskog retinoinskog receptora gama vezanog za sintetički agonist BMS961

Transkripcioni faktori i intracelularni receptori

(1) Osnovni domeni

(1.1) Osnovni leucin rajsferšlus (bZIP)	Aktivirajući transkripcioni faktor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NFIL3 • NRL • NRF1 • XBP1
(1.2) Osnovni heliks-petlja-heliks (bHLH)	ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatorni faktori (MyoD, Myogenin, MYF5, MYF6) • Neurogenini (1, 2, 3) • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Pho4 • Scleraxis • TAL (1, 2) • Twist • USF1
(1.3) bHLH-ZIP	AP-4 • MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.4) NF-1	NFI (A, B, C, X) • SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)
(1.5) RF-X	RFX (1, 2, 3, 4, 5, ANK)
(1.6) Osnovni heliks-razmak-heliks (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Cink prst DNA-vezujući domeni

(2.1) Nuklearni receptor (Cys₄)	podfamilija 1 (Tiroidni hormon (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) podfamilija 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testikularni receptor (2, 4), TLX) podfamilija 3 (Steroidni hormon (Androgen, Estrogen (α, β), Glukokortikoid, Mineralokortikoid, Progesteron), Estrogen-vezani (α, β, γ)) podfamilija 4 NUR (NGFIB, NOR1, NURR1) • podfamilija 5 (LRH-1, SF1) • podfamilija 6 (GCNF) • podfamilija 0 (DAX1, SHP)
(2.2) Drugi Cys₄	GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3) • TRPS1
(2.3) Cys₂His₂	Generalni transkripcioni faktori (TFIIA, TFIIB, TFIID, TFIIE, TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 • BCL (6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • GFI1 • GLI-Kruppel familija (1, 2, 3, REST, S2, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 17) • MTF1 • MYT1 • OSR1 • SP (1, 2, 4, 7) • WT1 • Zbtb7 (7A, 7B) • ZBTB (16, 17, 20, 32, 33, 40) • cink prst (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 649, 655)
(2.4) Cys₆	HIVEP1
(2.5) Naizmenična kompozicija	AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B

(3) Heliks-zavoj-heliks domeni

(3.1) Homeodomen	ARX • CDX (1, 2) • CRX • CUTL1 • DBX (1, 2) • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • IRX (1, 2, 3, 4, 5, 6, MKX) • LMX (1A, 1B) • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) • PBX (1, 2, 3) • PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) • PITX (1, 2, 3) • POU domen (PIT-1, BRN-3: A, B, C, Oktamer transkripcioni faktor: 1, 2, 3/4, 6, 7, 11) • OTX (1, 2) • PDX1 • ZEB (1, 2)
(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
(3.3) Fork glava / winged heliks	E2F (1, 2, 3, 4, 5) • FOX proteini (C1, C2, D3, E1, G1, H1, K2, L2, M1, N3, O1, O3, O4, P1, P2, P3)
(3.4) Faktori toplotnog šoka	HSF (1, 2, 4)
(3.5) Triptofan klasteri	ELF (2, 4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2, SPIB) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatorni faktori (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domen	transkripcioni pojačivač faktor (1, 2, 3, 4)

(4) β-Scaffold faktori sa manjim žljebnim kontaktima

(4.1) Rel homologni region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)
(4.3) p53	p53 • TBX (1, 2, 3, 5, 19, 21, 22, Brahiuri, TBR1)
(4.4) MADS kutija	Mef2 (A, B, C, D) • SRF
(4.6) TATA vezujući proteini	TBP • TBPL1
(4.7) Grupa visoke pokretljivosti	HMGB (1, 2, 3) • HNF (1A, 1B) • LEF1 • SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) • SRY • SSRP1 • TCF (3, 4) • TOX (1, 2, 3, 4)
(4.10) Domen hladnog šoka	CSDA, YBX1
(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Drugi transkripcioni faktori

(0.2) HMGI(Y)	HMGA (1, 2) • HBP1
(0.3) Džep domen	Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-vezani faktori	Apetala 2 • EREBP • B3
(0.6) Razno	ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFY (A, B, C) • Ro/Sigma