Malonatna dekarboksilaza zavisna od biotina
| Biotin-zavisna malonatna dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.1.89 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Malonatna dekarboksilaza zavisna od biotina (EC 4.1.1.89, malonat dekarboksilaza (sa biotinom), malonat dekarboksilaza) je enzim sa sistematskim imenom malonat karboksilijaza (biotin-zavisna).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- malonat + H+ acetat + CO2
Pozanat su dva tipa malonatne dekarboksilaze. Oba su multienzimski kompleksi.
Reference
- ↑ Hilbi, H., Dehning, I., Schink, B. and Dimroth, P. (1992). „Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme”. Eur. J. Biochem. 207: 117-123. PMID 1628643.
- ↑ Hilbi, H. and Dimroth, P. (1994). „Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase”. Arch. Microbiol. 162: 48-56. PMID 18251085.
- ↑ Berg, M., Hilbi, H. and Dimroth, P. (1996). „The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group”. Biochemistry 35: 4689-4696. PMID 8664258.
- ↑ Berg, M., Hilbi, H. and Dimroth, P. (1997). „Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function”. Eur. J. Biochem. 245: 103-115. PMID 9128730.
- ↑ Micklefield, J., Harris, K.J., Gröger, S., Mocek, U., Hilbi, H., Dimroth, P. and Floss, H.G. (1995). „Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention”. J. Am. Chem. Soc. 117: 1153-1154.
- ↑ Kim, Y.S. (2002). „Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application”. J. Biochem. Mol. Biol. 35: 443-451. PMID 12359084.
- ↑ Dimroth, P. and Hilbi, H. (1997). „Enzymic and genetic basis for bacterial growth on malonate”. Mol. Microbiol. 25: 3-10. PMID 11902724.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Biotin-dependent+malonate+decarboxylase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
