Lizin-tRNK ligaza
Lizin-tRNK ligaza | |||||||||
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Identifikatori | |||||||||
EC broj | 6.1.1.6 | ||||||||
CAS broj | 9031-26-9 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Lizin-tRNK ligaza (EC 6.1.1.6, lizil-tRNK sintetaza, lizil-transfer ribonukleat sintetaza, lizil-transfer RNK sintetaza, L-lizin-transfer RNK ligaza, lizin-tRNK sintetaza, lizinska translaza) je enzim sa sistematskim imenom L-lizin:tRNKLis ligaza (formira AMP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + L-lizin + tRNKLys AMP + difosfat + L-lizil-tRNKLys
Reference
- ↑ Allen, E.H., Glassman, E. and Schweet, R.S. (1960). „Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes”. J. Biol. Chem. 235: 1061-1067. PMID 13792726.
- ↑ Chiumecka, V., von Tigerstrom, M., D'Obrenan, P. and Smith, C.J. (1969). „Purification and properties of lysyl transfer ribonucleic acid synthetase from bakers' yeast”. J. Biol. Chem. 244: 5481-5488. PMID 4310598.
- ↑ Lagerkvist, U., Rymo, L., Lindqvist, O. and Andersson, E. (1972). „Some properties of crystals of lysine transfer ribonucleic acid ligase from yeast”. J. Biol. Chem. 247: 3897-3899. PMID 4555953.
- ↑ Stern, R. and Mehler, A.H. (1965). „Lysyl-sRNA synthetase from Escherichia coli”. Biochem. Z. 342: 400-409. PMID 4284804.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Lysine---tRNA+ligase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6