Homogentisat 1,2-dioksigenaza
| Homogentisat 1,2-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.13.11.5 | ||||||||
| CAS broj | 9029-49-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Homogentisat 1,2-dioksigenaza (EC 1.13.11.5, homogentisikaza, homogentisatna oksigenaza, homogentisatna dioksigenaza, homogentisatna oksidaza, homogentisinska kiselina oksidaza, homogentisinska kiselina oksigenaza, homogentisinska oksigenaza) je enzim sa sistematskim imenom homogentisat:kiseonik 1,2-oksidoreduktaza (deciklizacija).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- homogentisat + O2 4-maleilacetoacetat
Za rad ovog enzima neohodan je Fe2+.
Reference
- ↑ Adachi, K., Iwayama, Y., Tanioka, H. and Takeda, Y. (1966). „Purification and properties of homogentisate oxygenase from Pseudomonas fluorescens”. Biochim. Biophys. Acta 118: 88-97. PMID 5954067.
- ↑ Crandall, D.I. and Halikis, D.N. (1954). „Homogentisic acid oxidase. I. Distribution in animal tissues and relation to tyrosine metabolism in rat kidney”. J. Biol. Chem. 208: 629-638. PMID 13174573.
- ↑ Hayaishi, O. (1963). „Direct oxygenation by O2, oxygenases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 8 (2nd izd.). New York: Academic Press. str. 353-371.
- ↑ Kita, H., Kamimoto, M., Senoh, S., Adachi, T. and Takeda, Y. (1965). „Cystallization and some properties of 3,4-dihydroxyphenylacetate-2,3-oxygenase”. Biochem. Biophys. Res. Commun. 18: 66-70. PMID 14265758.
- ↑ Knox, W.E. and Edwards, S.W. (1955). „Homogentisate oxidase of liver.”. J. Biol. Chem. 216: 479-487. PMID 13271328.
- ↑ Ravdin, R.G. and Crandall, D.I. (1951). „The enzymatic conversion of homogentisic acid to 4-fumarylacetoacetic acid”. J. Biol. Chem. 189: 137-149. PMID 14832225.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Hayaishi, O. (1963). „Direct oxygenation by O2, oxygenases”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 8 (2nd izd.). New York: Academic Press. str. 353-371.
Spoljašnje veze
- MeSH Homogentisate+1,2-dioxygenase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
