GMP sintaza (hidrolizacija glutamina)
| GMP sintaza (hidrolizacija glutamina) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 6.3.5.2 | ||||||||
| CAS broj | 37318-71-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GMP sintaza (hidrolizacija glutamina) (EC 6.3.5.2, GMP sintetaza (glutaminska hidroliza), guanilatna sintetaza (glutaminska hidroliza), guanozin monofosfatna sintetaza (glutaminska hidroliza), ksantozin 5'-fosfatna amidotransferaza, guanozin 5'-monofosfatna sintetaza) je enzim sa sistematskim imenom ksantozin-5'-fosfat:L-glutamin amido-ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ATP + XMP + L-glutamin + H2O AMP + difosfat + GMP + L-glutamat
Reference
- ↑ Abrams, R. and Bentley, M. (1959). „Biosynthesis of nucleic acid purines. III. Guanosine 5′-phosphate formation from xanthosine 5′-phosphate and L-glutamine”. Arch. Biochem. Biophys. 79: 91-110.
- ↑ Lagerkvist, U. (1958). „Biosynthesis of guanosine 5′-phosphate. II. Amination of xanthosine 5′-phosphate by purified enzyme from pigeon liver”. J. Biol. Chem. 233: 143-149. PMID 13563458.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH GMP+synthase+(glutamine-hydrolysing)
- p
- r
- u
Proteini: enzimi
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
GMP_sintaza_(hidrolizacija_glutamina)