Fosducin

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Fosducin

PDB prikaz baziran na 2trc.

Dostupne strukture

2trc

Identifikatori

Simboli

PDC; PhLP; MEKA; PHD; PhLOP

Vanjski ID

OMIM: 171490 MGI: 98090 HomoloGene: 1950 GeneCards: PDC Gene

Ontologija gena
Molekularna funkcija	• fosfolipazna inhibitorna aktivnost
Celularna komponenta	• rastvorna frakcija • citoplazma
Biološki proces	• signalini put G-protein spregnutog receptora • vizuelna percepcija • fototransdukcija • respons na stimulus

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

5132

20028

Ensembl

ENSG00000116703

ENSMUSG00000006007

UniProt

P20941

Q9QW08

RefSeq (mRNA)

NM_002597

NM_024458

RefSeq (protein)

NP_002588

NP_077778

Lokacija (UCSC)

Chr 1:
184.68 - 184.7 Mb

Chr 1:
152.08 - 152.1 Mb

PubMed pretraga

[1]

[2]

Fosducin, takođe poznat kao PDC, je ljudski protein i gen.^[1] On pripada fosducin familiji of proteina.

Ovaj gen kodira fosfoprotein, koji je lociran u vanjski i unutarnji segmentima štapićastih ćelija mrežnjače. Ovaj protein može da sudeluje u regulaciji vizuelne fototransdukcije ili u integraciji fotoreceptorskog metabolizama. On modulira fototransdukcionu kaskadu putem interakcije sa beta i gama podjedinicama retinalnog G-proteina transducina. Vezivanjem za te dve podjedinice transducin će ostati vezan za alfa podjedinicu duže. To produžava trajanje vizuelne pobude.

Ovaj gen je potencijalni kandidat za retinitis pigmentosa i Ušerov sindrom tipa II. Alternativno splajsovane transkriptne varijante koje kodiraju različite izoforme su bile identifikovane.^[1]

Reference

↑ ^1,0 ^1,1 „Entrez Gene: PDC phosducin”.

Literatura

Abe T, Nakabayashi H, Tamada H, et al. (1990). „Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland.”. Gene 91 (2): 209–15. DOI:10.1016/0378-1119(90)90090-E. PMID 2210381.
Watanabe Y, Kawasaki K, Miki N, Kuo CH (1990). „Isolation and analysis of the human MEKA gene encoding a retina-specific protein.”. Biochem. Biophys. Res. Commun. 170 (2): 951–6. DOI:10.1016/0006-291X(90)92183-Z. PMID 2383274.
Lee RH, Brown BM, Lolley RN (1990). „Protein kinase A phosphorylates retinal phosducin on serine 73 in situ.”. J. Biol. Chem. 265 (26): 15860–6. PMID 2394752.
Hawes BE, Touhara K, Kurose H, et al. (1994). „Determination of the G beta gamma-binding domain of phosducin. A regulatable modulator of G beta gamma signaling.”. J. Biol. Chem. 269 (47): 29825–30. PMID 7961975.
Abe T, Kikuchi T, Shinohara T (1994). „The sequence of the human phosducin gene (PDC) and its 5'-flanking region.”. Genomics 19 (2): 369–72. DOI:10.1006/geno.1994.1072. PMID 8188267.
Sparkes RS, Lee RH, Shinohara T, et al. (1994). „Assignment of the phosducin (PDC) gene to human chromosome 1q25-1q32.1 by somatic cell hybridization and in situ hybridization.”. Genomics 18 (2): 426–8. DOI:10.1006/geno.1993.1490. PMID 8288249.
Ding C, Li X, Griffin CA, et al. (1994). „The gene for human phosducin (PDC), a soluble protein that binds G-protein beta gamma dimers, maps to 1q25-q31.1.”. Genomics 18 (2): 457–9. DOI:10.1006/geno.1993.1501. PMID 8288259.
Boekhoff I, Touhara K, Danner S, et al. (1997). „Phosducin, potential role in modulation of olfactory signaling.”. J. Biol. Chem. 272 (7): 4606–12. DOI:10.1074/jbc.272.7.4606. PMID 9020189.
Barhite S, Thibault C, Miles MF (1998). „Phosducin-like protein (PhLP), a regulator of G beta gamma function, interacts with the proteasomal protein SUG1.”. Biochim. Biophys. Acta 1402 (1): 95–101. DOI:10.1016/S0167-4889(97)00141-9. PMID 9551090.
Zhu X, Craft CM (1998). „Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1.”. Mol. Vis. 4: 13. PMID 9701609.
Craft CM, Xu J, Slepak VZ, et al. (1998). „PhLPs and PhLOPs in the phosducin family of G beta gamma binding proteins.”. Biochemistry 37 (45): 15758–72. DOI:10.1021/bi980921a. PMID 9843381.
Carpten JD, Makalowska I, Robbins CM, et al. (2000). „A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region.”. Genomics 64 (1): 1–14. DOI:10.1006/geno.1999.6051. PMID 10708513.
Zhu X, Craft CM (2000). „The carboxyl terminal domain of phosducin functions as a transcriptional activator.”. Biochem. Biophys. Res. Commun. 270 (2): 504–9. DOI:10.1006/bbrc.2000.2414. PMID 10753654.
Zhu X, Craft CM (2000). „Modulation of CRX transactivation activity by phosducin isoforms.”. Mol. Cell. Biol. 20 (14): 5216–26. DOI:10.1128/MCB.20.14.5216-5226.2000. PMC 85970. PMID 10866677.
Ruiz-Gómez A, Humrich J, Murga C, et al. (2000). „Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.”. J. Biol. Chem. 275 (38): 29724–30. DOI:10.1074/jbc.M001864200. PMID 10884381.
Nakano K, Chen J, Tarr GE, et al. (2001). „Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments.”. Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4693–8. DOI:10.1073/pnas.071067198. PMC 31896. PMID 11287646.
Thulin CD, Savage JR, McLaughlin JN, et al. (2001). „Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding.”. J. Biol. Chem. 276 (26): 23805–15. DOI:10.1074/jbc.M101482200. PMID 11331285.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). „Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts.”. Mol. Vis. 8: 196–204. PMID 12107411.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Margulis A, Dang L, Pulukuri S, et al. (2002). „Presence of phosducin in the nuclei of bovine retinal cells.”. Mol. Vis. 8: 477–82. PMID 12500174.