Denileukin diftitoks
Klinički podaci | |
---|---|
AHFS/Drugs.com | diftitox.html Monografija |
Identifikatori | |
CAS broj | 173146-27-5 |
ATC kod | L01XX29 |
DrugBank | DB00004 |
ChEMBL[1] | CHEMBL1201550 Y |
Hemijski podaci | |
Formula | C2560H4042N678O799S17 |
Mol. masa | 57647,3 g/mol |
Farmakokinetički podaci | |
Poluvreme eliminacije | 70-80 min |
Farmakoinformacioni podaci | |
Trudnoća | ? |
Pravni status | |
Način primene | Intravenozno |
Denileukin diftitoks (Ontak) je antineoplastični agens, dizajnirani protein koji je kombinacija interleukina 2 i toksina difterije. Ovaj molekul se vezuje za interleukin-2 receptore[2] i unosi toksin difterije u ćelija koje izražavaju te receptore, što dovodi do njihove smrti. Denileukin diftitoks se proizvodi u E. coli ekspresioni sistem.[3][4][5][6]
Reference
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Turturro F (2007). „Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders”. Expert Rev Anticancer Ther 7 (1): 11–7. DOI:10.1586/14737140.7.1.11. PMID 17187516.
- ↑ Turturro F: Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders. Expert Rev Anticancer Ther. 2007 Jan;7(1):11-7. PMID 17187516
- ↑ Park M, Liu GT, Piltz-Seymour J, Wisda CL, Rook AH, Junkins-Hopkins JM, Nasta SD, Kim EJ: Vision loss following denileukin diftitox treatment: a case report of possible posterior ischemic optic neuropathy. Leuk Lymphoma. 2007 Apr;48(4):808-11. PMID 17454642
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMC 3013709. PMID 21059682.
- ↑ David S. Wishart, Craig Knox, An Chi Guo, Dean Cheng, Savita Shrivastava, Dan Tzur, Bijaya Gautam, and Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMC 2238889. PMID 18048412.
Literatura
- Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
- Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.
Spoljašnje veze
Portal Medicina | |
Portal Hemija |
Denileukin diftitoks na Wikimedijinoj ostavi
- Denileukin diftitox