CTP sintaza

CTP sintetaza

Identifikatori

EC broj

6.3.4.2

CAS broj

9023-56-7

IntEnz

IntEnz view

BRENDA

BRENDA entry

ExPASy

NiceZyme view

KEGG

KEGG entry

MetaCyc

metabolic pathway

PRIAM

profile

PDB

RCSB PDB PDBe PDBj PDBsum

Pretraga
PMC	articles
PubMed	articles
NCBI Protein	search

CTP sintaza (EC 6.3.4.2, UTP—amonijak ligaza, citidin trifosfatna sintetaza, uridin trifosfatna aminaza, citidin 5'-trifosfatna sintetaza) je enzim sa sistematskim imenom UTP:amonijak ligaza (formira ADP).^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + UTP + NH₃

\rightleftharpoons

ADP + fosfat + CTP

Glutamin može da zameni NH₃.

Reference

↑ Lieberman, I. (1956). „Enzymatic amination of uridine triphosphate to cytidine triphosphate”. J. Biol. Chem. 222: 765-775. PMID 13367044.
↑ Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr. (1969). „Subunit structures and interactions of CTP synthetase”. Fed. Proc. 28: 342-342.

Literatura

Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Vanjske veze

MeSH CTP+synthase

Proteini: enzimi

Teme

Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima

Tipovi

EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6