COPG

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Koatomerni proteinski kompleks, podjedinica gama

PDB prikaz baziran na 1pzd.

Dostupne strukture

1pzd, 1r4x

Identifikatori

Simboli

COPG; COPG1; FLJ21068

Vanjski ID

MGI: 1858696 HomoloGene: 56745 GeneCards: COPG Gene

Ontologija gena
Molekularna funkcija	• aktivnost strukturnog molekula • proteinsko vezivanje
Celularna komponenta	• Goldžijeva membrana • citoplazmam • Goldžijev aparat • Goldžem potpomognuta vezikula • citosol • membrana • membranski pokrivač • COPI vezikularni pokrivač • citoplazmatična vezikula
Biološki proces	• intracelularni proteinski transport • retrogradni vezikulom posredovani transport, Goldži do ER • celularna membranska organizacija • vezikulom posredovani transport • COPI pokrivač Goldžijevog aparata

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

22820

54161

Ensembl

ENSG00000181789

ENSMUSG00000030058

UniProt

Q9Y678

n/a

RefSeq (mRNA)

NM_016128

NM_017477

RefSeq (protein)

NP_057212

NP_059505

Lokacija (UCSC)

Chr 3:
128.97 - 129 Mb

Chr 6:
87.84 - 87.86 Mb

PubMed pretraga

[1]

[2]

Koatomerna podjedinica gama je protein koji je kod ljudi kodiran COPG genom.^[1]^[2]

Interakcije

Za COPG je pokazano da formira interakcije sa dopaminskim receptorom D1,^[3] COPZ1^[4]^[5] i COPB1.^[1]^[6]

Reference

↑ ^1,0 ^1,1 Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (February 2001). „Identification and characterization of novel isoforms of COP I subunits”. J Biochem 128 (5): 793–801. PMID 11056392.
↑ „Entrez Gene: COPG coatomer protein complex, subunit gamma”.
↑ Bermak, Jason C; Li Ming, Bullock Clayton, Weingarten Paul, Zhou Qun-Yong (February 2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. (Germany) 81 (2): 77–85. DOI:10.1078/0171-9335-00222. ISSN 0171-9335. PMID 11893085.
↑
↑ Faulstich, D; Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland F T, Tschochner H (October 1996). „Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex”. J. Cell Biol. (UNITED STATES) 135 (1): 53–61. DOI:10.1083/jcb.135.1.53. ISSN 0021-9525. PMC 2121028. PMID 8858162.
↑ Lowe, M; Kreis T E (November 1996). „In vivo assembly of coatomer, the COP-I coat precursor”. J. Biol. Chem. (UNITED STATES) 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. ISSN 0021-9258. PMID 8940050.

Literatura

Lowe M, Kreis TE (1997). „In vivo assembly of coatomer, the COP-I coat precursor.”. J. Biol. Chem. 271 (48): 30725–30. DOI:10.1074/jbc.271.48.30725. PMID 8940050.
Pavel J, Harter C, Wieland FT (1998). „Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.”. Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. DOI:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
Fischer KD, Helms JB, Zhao L, Wieland FT (2000). „Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles.”. Methods 20 (4): 455–64. DOI:10.1006/meth.2000.0958. PMID 10720466.
Eugster A, Frigerio G, Dale M, Duden R (2000). „COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.”. EMBO J. 19 (15): 3905–17. DOI:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
Hu RM, Han ZG, Song HD, et al. (2000). „Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”. Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. DOI:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). „RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.”. Mol. Biol. Cell 11 (9): 3155–68. PMC 14982. PMID 10982407.
Hahn Y, Lee YJ, Yun JH, et al. (2000). „Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution.”. FEBS Lett. 482 (1–2): 31–6. DOI:10.1016/S0014-5793(00)02033-0. PMID 11018518.
Paulsson KM, Kleijmeer MJ, Griffith J, et al. (2002). „Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum”. J. Biol. Chem. 277 (21): 18266–71. DOI:10.1074/jbc.M201388200. PMID 11884415.
Bermak JC, Li M, Bullock C, et al. (2002). „Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus”. Eur. J. Cell Biol. 81 (2): 77–85. DOI:10.1078/0171-9335-00222. PMID 11893085.
Kanzaki M, Watson RT, Hou JC, et al. (2003). „Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes”. Mol. Biol. Cell 13 (7): 2334–46. DOI:10.1091/mbc.01-10-0490. PMC 117317. PMID 12134073.
Xu Y, Martin S, James DE, Hong W (2003). „GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus”. Mol. Biol. Cell 13 (10): 3493–507. DOI:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rohde HM, Cheong FY, Konrad G, et al. (2004). „The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex”. J. Biol. Chem. 278 (52): 52689–99. DOI:10.1074/jbc.M307983200. PMID 14527956.
Watson PJ, Frigerio G, Collins BM, et al. (2004). „Gamma-COP appendage domain - structure and function”. Traffic 5 (2): 79–88. DOI:10.1111/j.1600-0854.2004.00158.x. PMID 14690497.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. DOI:10.1038/msb4100134. PMC 1847948. PMID 17353931.