Akrozin

Akrozin
Identifikatori
EC broj 3.4.21.10
CAS broj 9068-57-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
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PubMed articles
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Akrozin (EC 3.4.21.10, akrozomalna proteinaza, akrozonaza, alfa-akrozin, beta-akrosin, upsilon-akrosin, akrozinska amidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno odvajanje: Arg-, Lys-

Ovaj enzim je izolovan iz spermatozoida.

Reference

  1. ↑ Müller-Esterl, W. and Fritz, H. (1981). „Sperm acrosin”. Methods Enzymol. 80: 621-632. PMID 7043204. 
  2. ↑ Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C (1989). „1 esterase and acrosin, for peptide p-nitroanilide substrates”. Biochim. Biophys. Acta 996: 89-94. PMID 2500154. 
  3. ↑ Keime, S., Adham, I.M. and Engel, W. (1990). „Nucleotide sequence and exon-intron organisation of the human proacrosin gene”. Eur. J. Biochem. 190: 195-200. PMID 2114285. 

Literatura

  • Elce JS, McIntyre EJ (1982). „Purification of bovine and human acrosin”. Can. J. Biochem. 60 (1): 8–14. DOI:10.1139/o82-002. PMID 6802470. 
  • Zheng X, Geiger M, Ecke S, et al. (1994). „Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa”. Am. J. Physiol. 267 (2 Pt 1): C466–72. PMID 7521127. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). „Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55–65. DOI:10.1101/gr.4039406. PMC 1356129. PMID 16344560. 
  • Klemm U, Müller-Esterl W, Engel W (1991). „Acrosin, the peculiar sperm-specific serine protease”. Hum. Genet. 87 (6): 635–41. PMID 1937464. 
  • Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). „Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment”. Nat. Methods 2 (1): 47–53. DOI:10.1038/nmeth726. PMID 15782160. 
  • Moreno RD, Hoshi M, Barros C (1999). „Functional interactions between sulphated polysaccharides and proacrosin: implications in sperm binding and digestion of zona pellucida”. Zygote 7 (2): 105–11. DOI:10.1017/S0967199499000453. PMID 10418103. 
  • Liu RZ, Lu YL, Xu ZG, et al. (2003). „[The effect of semen antisperm antibody on human sperm acrosin activity]”. Zhonghua Nan Ke Xue 9 (4): 252–3. PMID 12931362. 
  • Steven FS, Griffin MM, Chantler EN (1982). „Inhibition of human and bovine sperm acrosin by divalent metal ions. Possible role of zinc as a regulator of acrosin activity”. Int. J. Androl. 5 (4): 401–12. DOI:10.1111/j.1365-2605.1982.tb00270.x. PMID 6815104. 
  • Marí SI, Rawe V, Biancotti JC, et al. (2003). „Biochemical and molecular studies of the proacrosin/acrosin system in patients with unexplained infertility”. Fertil. Steril. 79 Suppl 3: 1676–9. PMID 12801583. 
  • Glogowski J, Demianowicz W, Piros B, Ciereszko A (1998). „Determination of acrosin activity of boar spermatozoa by the clinical method: optimization of the assay and changes during short-term storage of semen”. Theriogenology 50 (6): 861–72. DOI:10.1016/S0093-691X(98)00191-5. PMID 10734459. 
  • Furlong LI, Veaute C, Vazquez-Levin MH (2005). „Binding of recombinant human proacrosin/acrosin to zona pellucida glycoproteins. II. Participation of mannose residues in the interaction”. Fertil. Steril. 83 (6): 1791–6. DOI:10.1016/j.fertnstert.2004.12.043. PMID 15950652. 
  • Furlong LI, Harris JD, Vazquez-Levin MH (2005). „Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC”. Fertil. Steril. 83 (6): 1780–90. DOI:10.1016/j.fertnstert.2004.12.042. PMID 15950651. 
  • Hartley JL, Temple GF, Brasch MA (2000). „DNA Cloning Using In Vitro Site-Specific Recombination”. Genome Res. 10 (11): 1788–95. DOI:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Collins JE, Wright CL, Edwards CA, et al. (2004). „A genome annotation-driven approach to cloning the human ORFeome”. Genome Biol. 5 (10): R84. DOI:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. 
  • Dubé C, Leclerc P, Baba T, et al. (2005). „The proacrosin binding protein, sp32, is tyrosine phosphorylated during capacitation of pig sperm”. J. Androl. 26 (4): 519–28. DOI:10.2164/jandrol.04163. PMID 15955892. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Zahn A, Furlong LI, Biancotti JC, et al. (2002). „Evaluation of the proacrosin/acrosin system and its mechanism of activation in human sperm extracts”. J. Reprod. Immunol. 54 (1–2): 43–63. DOI:10.1016/S0165-0378(01)00080-8. PMID 11839395. 
  • Howes E, Pascall JC, Engel W, Jones R (2001). „Interactions between mouse ZP2 glycoprotein and proacrosin; a mechanism for secondary binding of sperm to the zona pellucida during fertilization”. J. Cell. Sci. 114 (Pt 22): 4127–36. PMID 11739644. 
  • Yudin AI, Vandevoort CA, Li MW, Overstreet JW (1999). „PH-20 but not acrosin is involved in sperm penetration of the macaque zona pellucida”. Mol. Reprod. Dev. 53 (3): 350–62. DOI:10.1002/(SICI)1098-2795(199907)53:3<350::AID-MRD11>3.0.CO;2-9. PMID 10369396. 

Vanjske veze

  • p
  • r
  • u
TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6