8-Ciklopentil-1,3-dimetilksantin |
(IUPAC) ime |
8-ciklopentil-1,3-dimetil-7H-purin-2,6-dion |
Klinički podaci |
Identifikatori |
CAS broj | 35873-49-5 |
ATC kod | nije dodeljen |
PubChem[1][2] | 1917 |
ChemSpider[3] | 1843 |
ChEMBL[4] | CHEMBL106265 Y |
Hemijski podaci |
Formula | C12H16N4O2 |
Mol. masa | 248,280 g/mol |
SMILES | eMolekuli & PubHem |
InChI | InChI=1S/C12H16N4O2/c1-15-10-8(11(17)16(2)12(15)18)13-9(14-10)7-5-3-4-6-7/h7H,3-6H2,1-2H3,(H,13,14) Y Key: SCVHFRLUNIOSGI-UHFFFAOYSA-N Y | |
Farmakoinformacioni podaci |
Trudnoća | ? |
Pravni status | Nije kontrolisan |
8-Ciklopentil-1,3-dimetilksantin (8-Ciklopentilteofilin, 8-CPT, CPX) je lek koji deluje kao potentan i selektivan antagonist adenozinskih receptora, sa izvesnom selektivnošću za A1 receptor, kao i neselektivni inhibitor fosfodiesteraze. On ima stimulišuće dejstvo u životinjskim studijama sa malo većom potencijom od kofeina.[5][6]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Spealman RD (1988). „Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism”. Psychopharmacology 95 (1): 19–24. PMID 3133696.
- ↑ Karcz-Kubicha M, Antoniou K, Terasmaa A, Quarta D, Solinas M, Justinova Z, Pezzola A, Reggio R, Müller CE, Fuxe K, Goldberg SR, Popoli P, Ferré S (July 2003). „Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration”. Neuropsychopharmacology 28 (7): 1281–91. DOI:10.1038/sj.npp.1300167. PMID 12700682.
Povezano
Inhibitori fosfodiesteraze |
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PDE1 | |
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PDE2 | |
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PDE3 | |
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PDE4 | |
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PDE5 | |
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PDE6 | |
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PDE7 | |
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PDE9 | |
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PDE10 | |
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Nonselektivni | |
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