4-Hidroksi-4-metil-2-oksoglutaratna aldolaza
| 4-Hidroksi-4-metil-2-oksoglutaratna aldolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.3.17 | ||||||||
| CAS broj | 37290-65-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
4-Hidroksi-4-metil-2-oksoglutaratna aldolaza (EC 4.1.3.17, piruvatna aldolaza, gama-metil-gama-hidroksi-alfa-ketoglutarinska aldolaza, 4-hidroksi-4-metil-2-ketoglutaratna aldolaza, 4-hidroksi-4-metil-2-oksoglutaratna piruvat-lijaza, HMG aldolaza, CHA aldolaza, 4-karboksi-4-hidroksi-2-oksoadipatna aldolaza) je enzim sa sistematskim imenom 4-hidroksi-4-metil-2-oksoglutarat piruvat-lijaza (formira piruvat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 4-hidroksi-4-metil-2-oksoglutarat 2 piruvat
- (2) 2-hidroksi-4-oksobutan-1,2,4-trikarboksilat oksaloacetat + piruvat
Za dejstvo ovog enzima je neophodan divalentni metalni jon.
Reference
- ↑ Tack, B.F., Chapman, P.J. and Dagley, S. (1972). „Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase”. J. Biol. Chem. 247: 6444-6449. PMID 5076765.
- ↑ Wood, W.A. (1972). „2-Keto-3-deoxy-6-phosphogluconic and related aldolases”. u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 281-302.
- ↑ Maruyama, K. (1983). „Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase”. J. Biochem. (Tokyo) 93: 557-565. PMID 6841353.
- ↑ Nogales, J., Canales, A., Jimenez-Barbero, J., Serra, B., Pingarron, J.M., Garcia, J.L. and Diaz, E. (2011). „Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida”. Mol. Microbiol. 79: 359-374. PMID 21219457.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Wood, W.A. (1972). „2-Keto-3-deoxy-6-phosphogluconic and related aldolases”. u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 281-302.
Spoljašnje veze
- MeSH 4-hydroxy-4-methyl-2-oxoglutarate+aldolase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
