ITPR3

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Inositol 1,4,5-trisphosphate receptor, type 3

Identificadores

ITPR3; IP3R; IP3R3

IDs externos

OMIM: 147267 MGI: 96624 HomoloGene: 1675 IUPHAR: IP₃R3 ChEMBL: 3904 GeneCards: ITPR3 Gene

Ontologia do gene
Função molecular	•inositol hexakisphosphate binding •intracellular ligand-gated calcium channel activity •inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity •protein binding •phosphatidylinositol binding •inositol 1,3,4,5 tetrakisphosphate binding •inositol 1,4,5 trisphosphate binding
Componente celular	•nuclear outer membrane •nucleoplasm •nucleolus •cytoplasm •endoplasmic reticulum •endoplasmic reticulum membrane •plasma membrane •integral component of plasma membrane •brush border •membrane •platelet dense tubular network membrane •neuronal cell body •myelin sheath •receptor complex •apical part of cell
Processo biológico	•energy reserve metabolic process •signal transduction •epidermal growth factor receptor signaling pathway •G-protein coupled receptor signaling pathway •activation of phospholipase C activity •positive regulation of cytosolic calcium ion concentration •blood coagulation •memory •fibroblast growth factor receptor signaling pathway •platelet activation •Fc-epsilon receptor signaling pathway •Fc-gamma receptor signaling pathway involved in phagocytosis •small molecule metabolic process •innate immune response •neurotrophin TRK receptor signaling pathway •inositol phosphate-mediated signaling •regulation of insulin secretion •sensory perception of bitter taste •sensory perception of sweet taste •sensory perception of umami taste •protein homooligomerization •protein heterooligomerization •response to calcium ion •long-term synaptic potentiation •calcium ion transport into cytosol •calcium ion transmembrane transport
Sources: Amigo / QuickGO

Ortólogos

Espécies

Humano

Rato

Entrez

3710

16440

Ensembl

ENSG00000096433

ENSMUSG00000042644

UniProt

Q14573

P70227

RefSeq (mRNA)

NM_002224

NM_080553

RefSeq (proteína)

NP_002215

NP_542120

Localização (UCSC)

Chr 6:
33.59 – 33.66 Mb

Chr 17:
27.06 – 27.12 Mb

Busca PubMed

[1]

[2]

ITPR3 (do inglês, inositol 1,4,5-triphosphate receptor, type 3) é uma proteína humana codificada pelo gene ITPR3.^[1] A proteína codificada por este gene é um receptor para o inositol trifosfato e um canal de cálcio.^[2]

Ver também

Receptor de inositol trifosfato

Referências

↑ «Entrez Gene: inositol 1»
↑ Yamamoto-Hino M, Sugiyama T, Hikichi K; et al. (1994). «Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors». Recept. Channels. 2 (1): 9–22. PMID 8081734 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)

Leitura de apoio

Kline CF, Cunha SR, Lowe JS; et al. (2008). «Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor.». J. Cell. Biochem. 104 (4): 1244–53. PMC 2858327. PMID 18275062. doi:10.1002/jcb.21704 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Oishi T, Iida A, Otsubo S; et al. (2008). «A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population.». J. Hum. Genet. 53 (2): 151–62. PMID 18219441. doi:10.1007/s10038-007-0233-3 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Hirose M, Stuyvers B, Dun W; et al. (2008). «Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells.». J. Mol. Cell. Cardiol. 45 (2): 176–84. PMC 2566512. PMID 18586264. doi:10.1016/j.yjmcc.2008.05.008 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Miyachi K, Iwai M, Asada K; et al. (2007). «Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with SjÃ¶gren's syndrome and other systemic rheumatic diseases.». Mod Rheumatol. 17 (2): 137–43. PMID 17437169. doi:10.1007/s10165-006-0555-6 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Tang TS, Guo C, Wang H; et al. (2009). «Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model.». J. Neurosci. 29 (5): 1257–66. PMC 2768402. PMID 19193873. doi:10.1523/JNEUROSCI.4411-08.2009 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Nagaleekar VK, Diehl SA, Juncadella I; et al. (2008). «IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program.». J. Immunol. 181 (12): 8315–22. PMC 2756541. PMID 19050248 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Bandyopadhyay BC, Swaim WD, Liu X; et al. (2005). «Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.». J. Biol. Chem. 280 (13): 12908–16. PMID 15623527. doi:10.1074/jbc.M410013200 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Kasri NN, Holmes AM, Bultynck G; et al. (2004). «Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins.». EMBO J. 23 (2): 312–21. PMC 1271747. PMID 14685260. doi:10.1038/sj.emboj.7600037 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Hattori M, Suzuki AZ, Higo T; et al. (2004). «Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.». J. Biol. Chem. 279 (12): 11967–75. PMID 14707143. doi:10.1074/jbc.M311456200 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Olsen JV, Blagoev B, Gnad F; et al. (2006). «Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.». Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Roach JC, Deutsch K, Li S; et al. (2006). «Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden.». Am. J. Hum. Genet. 79 (4): 614–27. PMC 1592562. PMID 16960798. doi:10.1086/507876 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Tojyo Y, Morita T, Nezu A, Tanimura A (2008). «The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca(2+) store.». J. Pharmacol. Sci. 107 (2): 138–50. PMID 18544901. doi:10.1254/jphs.08021FP !CS1 manut: Nomes múltiplos: lista de autores (link)
Singleton PA, Bourguignon LY (2004). «CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation.». Exp. Cell Res. 295 (1): 102–18. PMID 15051494. doi:10.1016/j.yexcr.2003.12.025
Ota T, Suzuki Y, Nishikawa T; et al. (2004). «Complete sequencing and characterization of 21,243 full-length human cDNAs.». Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Ogasawara H (2008). «The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection.». J. Neurosci. 28 (17): 4293–4. PMID 18434505. doi:10.1523/JNEUROSCI.0644-08.2008
Qu HQ, Marchand L, Szymborski A; et al. (2008). «The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II.». Genes Immun. 9 (3): 264–6. PMID 18340361. doi:10.1038/gene.2008.12 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)
Wu Z, Bowen WD (2008). «Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.». J. Biol. Chem. 283 (42): 28198–215. PMC 2661391. PMID 18539593. doi:10.1074/jbc.M802099200
MartÃnez-GÃ³mez A, Dent MA (2007). «Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.». Neuroreport. 18 (5): 447–50. PMID 17496801. doi:10.1097/WNR.0b013e32805868a6 soft hyphen character character in |autor= at position 6 (ajuda)
Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). «IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.». J. Biol. Chem. 283 (46): 31284–8. PMID 18826956. doi:10.1074/jbc.C800184200 !CS1 manut: Nomes múltiplos: lista de autores (link)
Sundivakkam PC, Kwiatek AM, Sharma TT; et al. (2009). «Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.». Am. J. Physiol., Cell Physiol. 296 (3): C403–13. PMC 2660268. PMID 19052258. doi:10.1152/ajpcell.00470.2008 !CS1 manut: Uso explícito de et al. (link) !CS1 manut: Nomes múltiplos: lista de autores (link)