BRCA2 |
---|
|
사용 가능한 구조 |
---|
PDB | 동원체 검색: PDBe RCSB |
---|
|
|
식별자 |
---|
다른 이름 | BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes |
---|
외부 ID | OMIM: 600185 MGI: 109337 HomoloGene: 41 GeneCards: BRCA2 |
---|
유전자 위치 (인간) |
---|
| 염색체 | 13번 염색체[1] |
---|
| 자리 | 13q13.1 | 시작 | 32,315,086 bp[1] |
---|
끝 | 32,400,268 bp[1] |
---|
|
유전자 위치 (쥐) |
---|
| 염색체 | 5번 염색체 (쥐)[2] |
---|
| 자리 | 5 G3|5 89.52 cM | 시작 | 150,446,095 bp[2] |
---|
끝 | 150,493,794 bp[2] |
---|
|
RNA 발현 패턴 |
---|
Bgee | 인간 | 쥐(동원체) |
---|
최상위 발현 | - 고환
- secondary oocyte
- ventricular zone
- 생식샘
- ganglionic eminence
- 과립구
- 골수세포
- 해면뼈
- stromal cell of endometrium
- 아킬레스건
|
| 최상위 발현 | - primary oocyte
- secondary oocyte
- 수정란
- tail of embryo
- 위판
- 세정관
- maxillary prominence
- genital tubercle
- 발목관절
- mandibular prominence
|
| 추가 참조 발현 데이터 |
|
---|
BioGPS | | 추가 참조 발현 데이터 |
|
---|
|
유전자 온톨로지 |
---|
분자 함수 | - DNA 결합
- H4 histone acetyltransferase activity
- H3 histone acetyltransferase activity
- protease binding
- histone acetyltransferase activity
- 단백질 결합
- gamma-tubulin binding
- single-stranded DNA binding
- protein C-terminus binding
- identical protein binding
| 세포 성분 | - 중심체
- BRCA2-MAGE-D1 complex
- 분비 과립
- 핵질
- microtubule organizing center
- 세포핵
- 세포골격
- lateral element
- 세포질
- 세포액
- 단백질을 포함한 복합체
| 생물학적 과정 | - chordate embryonic development
- nucleotide-excision repair
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- DNA recombination
- regulation of cytokinesis
- replication fork protection
- centrosome duplication
- male meiosis I
- negative regulation of mammary gland epithelial cell proliferation
- positive regulation of mitotic cell cycle
- chromosome organization
- female gonad development
- inner cell mass cell proliferation
- positive regulation of transcription, DNA-templated
- telomere maintenance via recombination
- brain development
- oocyte maturation
- histone H3 acetylation
- spermatogenesis
- intrinsic apoptotic signaling pathway in response to DNA damage
- establishment of protein localization to telomere
- histone H4 acetylation
- cellular response to DNA damage stimulus
- 세포 주기
- 세포 증식
- response to gamma radiation
- response to UV-C
- response to X-ray
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- mitotic recombination-dependent replication fork processing
- double-strand break repair via homologous recombination
- DNA 수선
- double-strand break repair
- mitotic cytokinesis
- 조혈
- response to nutrient
- meiotic DNA repair synthesis involved in reciprocal meiotic recombination
- mammary gland development
- homologous chromosome orientation involved in meiotic metaphase I plate congression
- response to estradiol
- multicellular organism growth
- DNA synthesis involved in double-strand break repair via homologous recombination
- meiotic recombination checkpoint signaling
| 출처: Amigo / QuickGO |
|
동원체 |
---|
종 | 인간 | 쥐 |
---|
앙트레 | | |
---|
앙상블 | | |
---|
유니프롯 | | |
---|
RefSeq (mRNA) | | |
---|
RefSeq(단백질) | | |
---|
위치(UCSC) | Chr 13: 32.32 – 32.4 Mb | Chr 5: 150.45 – 150.49 Mb |
---|
PubMed 검색 | [3] | [4] |
---|
|
위키데이터 |
|