PTEN

PTEN
Struktur yang tersedia PDB Pencarian Ortolog: PDBe RCSB Daftar kode id PDB 4O1V, 1D5R, 2KYL, 5BZX, 5BUG, 5BZZ
Pengidentifikasi
Alias	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, Phosphatase and tensin homolog, PTENbeta
ID eksternal	OMIM: 601728 MGI: 109583 HomoloGene: 265 GeneCards: PTEN
Lokasi gen (Manusia) Kr. Kromosom 10 (manusia)[1] Pita 10q23.31 Awal 87,862,638 bp[1] Akhir 87,971,930 bp[1]
Lokasi gen (Tikus) Kr. Kromosom 19 (tikus)[2] Pita 19 C1|19 28.14 cM Awal 32,734,897 bp[2] Akhir 32,803,560 bp[2]
Ontologi gen Fungsi molekuler • phosphoprotein phosphatase activity • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity • phosphatidylinositol-3-phosphatase activity • protein serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity • enzyme binding • platelet-derived growth factor receptor binding • GO:0001948, GO:0016582 Ikatan protein plasma • protein kinase binding • phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity • anaphase-promoting complex binding • pengikatan protein identik • hydrolase activity • lipid binding • ubiquitin-specific protease binding • ionotropic glutamate receptor binding • protein tyrosine kinase binding • inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity • PDZ domain binding Komponen seluler • sitoplasma • postsynaptic membrane • extracellular region • mitokondria • neuron projection • cytoplasmic side of plasma membrane • Inti sel • cell projection • dendritic spine • myelin sheath adaxonal region • Schmidt-Lanterman incisure • membran plasma apikal • Membran sel • PML body • nucleoplasm • sitosol • postsynaptic cytosol Proses biologis • multicellular organismal response to stress • regulation of neuron projection development • response to zinc ion • positive regulation of TRAIL-activated apoptotic signaling pathway • response to organic substance • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle • regulation of B cell apoptotic process • Angiogenesis • positive regulation of ERK1 and ERK2 cascade • negative regulation of epithelial cell proliferation • long-term depression • positive regulation of excitatory postsynaptic potential • cell population proliferation • response to ethanol • neuron projection development • respons seluler terhadap hipoksia • negative regulation of cell size • negative regulation of cell population proliferation • prepulse inhibition • regulation of myeloid cell apoptotic process • male mating behavior • locomotory behavior • dentate gyrus development • positive regulation of apoptotic signaling pathway • inositol phosphate metabolic process • response to arsenic-containing substance • Ingatan • forebrain morphogenesis • dendritic spine morphogenesis • heart development • central nervous system development • negative regulation of axonogenesis • regulation of cellular localization • synapse maturation • belajar atau mengingat • perilaku sosial • Sinaptogenesis • cellular response to decreased oxygen levels • prostate gland growth • platelet-derived growth factor receptor signaling pathway • negative regulation of dendritic spine morphogenesis • brain morphogenesis • GO:0033128 negative regulation of protein phosphorylation • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of cellular component size • response to nutrient • negative regulation of synaptic vesicle clustering • postsynaptic density assembly • GO:0016576 protein dephosphorylation • protein stabilization • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • response to glucose • perkembangan sistem saraf • adult behavior • phosphatidylinositol dephosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • response to inorganic substance • canonical Wnt signaling pathway • phosphatidylinositol biosynthetic process • negative regulation of organ growth • negative regulation of ribosome biogenesis • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • locomotor rhythm • central nervous system myelin maintenance • regulation of axon regeneration • response to estradiol • response to ATP • negative regulation of phagocytosis • GO:1904578 response to organic cyclic compound • protein kinase B signaling • cardiac muscle tissue development • metabolisme lipid • GO:0010260 penuaan • neuron-neuron synaptic transmission • negative regulation of excitatory postsynaptic potential • presynaptic membrane assembly • regulation of cell cycle • maternal behavior • rhythmic synaptic transmission • positive regulation of cell population proliferation • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • Migrasi sel • negative regulation of myelination • inositol phosphate dephosphorylation • regulation of synaptic transmission, GABAergic • endothelial cell migration • central nervous system neuron axonogenesis • long-term potentiation • peptidyl-tyrosine dephosphorylation • negative regulation of axon regeneration • negative regulation of cardiac muscle cell proliferation • GO:0090623, GO:1903835, GO:0007092, GO:0051488, GO:0051487 positive regulation of ubiquitin protein ligase activity • protein deubiquitination • negative regulation of epithelial to mesenchymal transition • negative regulation of keratinocyte migration • cellular response to electrical stimulus • negative regulation of wound healing, spreading of epidermal cells • negative regulation of phosphatidylinositol 3-kinase signaling • GO:1901313 positive regulation of gene expression • positive regulation of cardiac muscle cell apoptotic process • response to activity • cellular response to insulin stimulus • cellular response to leptin stimulus • positive regulation of neuron differentiation • cellular response to ethanol • negative regulation of potassium ion transmembrane transporter activity • cellular response to nerve growth factor stimulus • cellular response to insulin-like growth factor stimulus • negative regulation of signaling receptor activity • negative regulation of protein kinase B signaling • GO:0097285 Apoptosis • negative regulation of cell migration • regulation of protein stability • negative regulation of focal adhesion assembly • negative regulation of vascular associated smooth muscle cell proliferation • transcription initiation from RNA polymerase II promoter • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of neuron projection development Sumber:Amigo / QuickGO
Ortolog
Spesies	Manusia	Tikus
Entrez	5728	19211
Ensembl	ENSG00000171862 ENSG00000284792	ENSMUSG00000013663
UniProt	P60484	O08586
RefSeq (mRNA)	NM_000314 NM_001304717 NM_001304718	NM_008960 NM_177096
RefSeq (protein)	NP_000305 NP_001291646 NP_001291647 NP_000305.3	NP_032986
Lokasi (UCSC)	Chr 10: 87.86 – 87.97 Mb	Chr 19: 32.73 – 32.8 Mb
Pencarian PubMed	[3]	[4]
Wikidata
Lihat/Sunting Manusia Lihat/Sunting Tikus

PTEN (bahasa Inggris: phosphatase and tensin homolog, PTEN) adalah berkas genetik pada kromosom 10 lokus 10q23.3 dengan ekspresietik berupa protein yang berfungsi sebagai enzim dengan nama PI3P. Mutasi genetik PTEN sering ditemukan pada banyak kasus kanker, sehingga gen ini sering disebut sebagai salah satu tumor suppressor.^[5]

Tidak seperti umumnya protein fosfatase tirosina, protein ekspresi PTEN lebih banyak mengkatalitik reaksi defosforilasi pada substrat fosfoinositida dan melakukan fungsinya sebagai penghambat tumor dengan menekan lintasan AKT/PKB.