POU5F1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/5/59/OCT4_prot.png/250px-OCT4_prot.png) |
Visualisation de la protéine Cristallisée OCT4 |
Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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1OCP, 3L1P |
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Identifiants |
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Aliases | POU5F1, OCT4, Octamer-binding transcription factor 4 |
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IDs externes | OMIM: 164177 MGI: 101893 HomoloGene: 8422 GeneCards: POU5F1 |
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Position du gène (Homme) |
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![Chromosome 6 humain](//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png) | Chr. | Chromosome 6 humain[1] |
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| Locus | 6p21.33 | Début | 31,164,337 bp[1] |
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Fin | 31,180,731 bp[1] |
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Position du gène (Souris) |
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![Chromosome 17 (souris)](//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/260px-Ideogram_house_mouse_chromosome_17.svg.png) | Chr. | Chromosome 17 (souris)[2] |
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| Locus | 17 B1|17 18.69 cM | Début | 35,816,915 bp[2] |
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Fin | 35,821,669 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - gonade
- right uterine tube
- muqueuse utérine
- human kidney
- body of pancreas
- body of stomach
- mucosa of transverse colon
- testicule
- left uterine tube
- fundus
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| Fortement exprimé dans | - blastocyste
- Épiblaste
- embryon
- morula
- morula
- primordial germ cell
- zygote
- masse cellulaire interne
- ligne primitive
- ooblast
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| Plus de données d'expression de référence |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/3/31/PBB_GE_POU5F1_208286_x_at_fs.png/250px-PBB_GE_POU5F1_208286_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/2/22/PBB_GE_POU5F1_210265_x_at_fs.png/250px-PBB_GE_POU5F1_210265_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/d/d9/PBB_GE_POU5F1_210905_x_at_fs.png/250px-PBB_GE_POU5F1_210905_x_at_fs.png) | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison ADN
- sequence-specific DNA binding
- liaison miARN
- DNA-binding transcription factor activity
- transcription factor binding
- transcription cis-regulatory region binding
- liaison protéique
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- ubiquitin protein ligase binding
- liaison ARN
| Composant cellulaire | - cytoplasme
- cytosol
- transcription regulator complex
- nucléoplasme
- noyau
- mitochondrie
| Processus biologique | - regulation of transcription, DNA-templated
- somatic stem cell population maintenance
- negative regulation of gene silencing by miRNA
- cell fate commitment involved in formation of primary germ layer
- endodermal cell fate specification
- morphogenèse d'une structure anatomique
- mRNA transcription by RNA polymerase II
- regulation of asymmetric cell division
- negative regulation of transcription by RNA polymerase II
- transcription by RNA polymerase II
- transcription, DNA-templated
- regulation of DNA methylation-dependent heterochromatin assembly
- développent d'un organisme multicellulaire
- cardiac cell fate determination
- response to wounding
- BMP signaling pathway involved in heart induction
- régulation de l'expression des gènes
- regulation of heart induction by regulation of canonical Wnt signaling pathway
- blastocyst development
- positive regulation of transcription by RNA polymerase II
- positive regulation of SMAD protein signal transduction
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | ENSG00000230336 ENSG00000206454 ENSG00000204531 ENSG00000237582 ENSG00000229094
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ENSG00000233911 ENSG00000235068 |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_203289 NM_001173531 NM_001285986 NM_001285987 NM_002701 |
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RefSeq (protéine) | NP_001167002 NP_001272915 NP_001272916 NP_002692 NP_976034
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NP_001272915.1 |
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Localisation (UCSC) | Chr 6: 31.16 – 31.18 Mb | Chr 17: 35.82 – 35.82 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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