HCN4 |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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2MNG, 3OTF, 3U11, 4HBN, 4KL1, 4NVP |
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Identifiants |
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Aliases | HCN4 |
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IDs externes | OMIM: 605206 MGI: 1298209 HomoloGene: 3997 GeneCards: HCN4 |
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Position du gène (Homme) |
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| Chr. | Chromosome 15 humain[1] |
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| Locus | 15q24.1 | Début | 73,319,859 bp[1] |
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Fin | 73,368,958 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 9 (souris)[2] |
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| Locus | 9|9 B | Début | 58,730,695 bp[2] |
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Fin | 58,770,458 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - muscle tibial antérieur
- atrium droit
- auricule droit
- apex of heart
- testicule
- ventricule gauche
- secondary oocyte
- ventricule droit
- gonade
- mucosa of ileum
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| Fortement exprimé dans | - myocarde
- myocarde
- Cardiac muscle tissue of myocardium
- conduction cardiaque
- sinus venosus
- atrium droit
- nœud sinusal
- septum transversum
- veine
- left horn of sinus venosus
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| Plus de données d'expression de référence |
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BioGPS | | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison nucléotide
- potassium channel activity
- cAMP binding
- sodium channel activity
- voltage-gated ion channel activity
- ion channel activity
- intracellular cAMP-activated cation channel activity
- identical protein binding
- voltage-gated potassium channel activity
- voltage-gated sodium channel activity
- voltage-gated potassium channel activity involved in SA node cell action potential depolarization
| Composant cellulaire | - integral component of membrane
- membrane
- intrinsic component of plasma membrane
- membrane plasmique
- perinuclear region of cytoplasm
- HCN channel complex
| Processus biologique | - cellular response to cGMP
- contraction musculaire
- sodium ion transmembrane transport
- sodium ion transport
- SA node cell action potential
- regulation of membrane potential
- regulation of ion transmembrane transport
- cation transport
- ion transport
- circulation sanguine
- regulation of membrane depolarization
- regulation of heart rate
- potassium ion transport
- transport transmembranaire
- potassium ion transmembrane transport
- regulation of cardiac muscle contraction
- regulation of heart rate by cardiac conduction
- cellular response to cAMP
- membrane depolarization during cardiac muscle cell action potential
- membrane depolarization during SA node cell action potential
- sodium ion import across plasma membrane
- regulation of cardiac muscle cell action potential involved in regulation of contraction
- potassium ion import across plasma membrane
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protéine) | | |
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Localisation (UCSC) | Chr 15: 73.32 – 73.37 Mb | Chr 9: 58.73 – 58.77 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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