CACNA1A |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/a/a3/CACNA1A.png/250px-CACNA1A.png) |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants |
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Aliases | CACNA1A |
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IDs externes | OMIM: 601011 MGI: 109482 HomoloGene: 56383 GeneCards: CACNA1A |
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Position du gène (Homme) |
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![Chromosome 19 humain](//upload.wikimedia.org/wikipedia/commons/thumb/5/54/Ideogram_human_chromosome_19.svg/300px-Ideogram_human_chromosome_19.svg.png) | Chr. | Chromosome 19 humain[1] |
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| Locus | 19p13.13 | Début | 13,206,442 bp[1] |
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Fin | 13,633,025 bp[1] |
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Position du gène (Souris) |
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![Chromosome 8 (souris)](//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Ideogram_house_mouse_chromosome_8.svg/260px-Ideogram_house_mouse_chromosome_8.svg.png) | Chr. | Chromosome 8 (souris)[2] |
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| Locus | 8 C2- C3|8 40.95 cM | Début | 85,065,268 bp[2] |
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Fin | 85,366,875 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - cerebellar hemisphere
- right hemisphere of cerebellum
- Brodmann area 23
- gyrus postcentral
- pont
- primary visual cortex
- gyrus frontal supérieur
- cellule endothéliale
- gyrus temporal moyen
- buccal mucosa cell
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| Fortement exprimé dans | - cerebellar cortex
- gyrus frontal supérieur
- lobe of cerebellum
- Vermis du cervelet
- primary visual cortex
- dentate gyrus of hippocampal formation granule cell
- Rostral migratory stream
- colliculus inférieur
- gyrus précentral
- neural layer of retina
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| Plus de données d'expression de référence |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/7/71/PBB_GE_CACNA1A_214933_at_fs.png/250px-PBB_GE_CACNA1A_214933_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/8/8d/PBB_GE_CACNA1A_206399_x_at_fs.png/250px-PBB_GE_CACNA1A_206399_x_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/1/12/PBB_GE_CACNA1A_210770_s_at_fs.png/250px-PBB_GE_CACNA1A_210770_s_at_fs.png) | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - liaison ion métal
- ion channel activity
- voltage-gated ion channel activity
- syntaxin binding
- liaison protéique
- voltage-gated calcium channel activity
- calcium channel activity
- high voltage-gated calcium channel activity
- amyloid-beta binding
| Composant cellulaire | - cytoplasme
- voltage-gated calcium channel complex
- prolongement cellulaire
- noyau
- membrane
- integral component of membrane
- membrane plasmique
- neuronal cell body
| Processus biologique | - calcium ion transport
- mort cellulaire
- transport transmembranaire
- membrane depolarization during action potential
- regulation of ion transmembrane transport
- ion transport
- transport
- regulation of insulin secretion
- calcium ion transmembrane transport
- positive regulation of cytosolic calcium ion concentration
- membrane depolarization
- transmission synaptique chimique
- modulation of chemical synaptic transmission
- calcium ion import
- response to amyloid-beta
- cellular response to amyloid-beta
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_023035 NM_000068 NM_001127221 NM_001127222 NM_001174080 |
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NM_001252059 NM_001252060 NM_001252061 NM_007578 |
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RefSeq (protéine) | |
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NP_000059 NP_001120693 NP_001120694 NP_001167551 NP_075461 |
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NP_001238988 NP_001238989 NP_001238990 NP_031604 |
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Localisation (UCSC) | Chr 19: 13.21 – 13.63 Mb | Chr 8: 85.07 – 85.37 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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