YBX1
![](http://upload.wikimedia.org/wikipedia/commons/thumb/0/03/Protein_YBX1_PDB_1h95.png/250px-Protein_YBX1_PDB_1h95.png)
YBX1 (engl. Y box binding protein 1) on proteiini, josta käytetään yleisesti myös nimeä YB-1. Nimen YB-1 antoivat proteiinin löytäneet tutkijat.[1]
Proteiinin nykyiset tutkimukset painottuvat kyseisen proteiinin osallisuudesta erilaisiin syöpätyyppeihin ja erityisesti etäpesäkkeisiin ja niiden torjuntaan.
YBX1-proteiinin on todettu vaikuttavan yhdessä RBBP6-,[2] PCNA-,[3][4] ANKRD2-,[5][6] SFRS9-,[7][8][9] ja CTCF-proteiinien[10][11] sekä P53-geenien kanssa.[5][12]
Lähteet
- ↑ YBX1 Y-box binding protein 1 [Homo sapiens (human) - Gene - NCBI] www.ncbi.nlm.nih.gov. Viitattu 22.3.2019.
- ↑ Moredreck Chibi, Mervin Meyer, Amanda Skepu, D. Jasper G Rees, Johanna C. Moolman-Smook, David J. R. Pugh: RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. Journal of Molecular Biology, 26.12.2008, nro 4, s. 908–916. PubMed:18851979. doi:10.1016/j.jmb.2008.09.060. ISSN 1089-8638. Artikkelin verkkoversio.
- ↑ T. Ise, G. Nagatani, T. Imamura, K. Kato, H. Takano, M. Nomoto: Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen. Cancer Research, 15.1.1999, nro 2, s. 342–346. PubMed:9927044. ISSN 0008-5472. Artikkelin verkkoversio.
- ↑ American Association for Cancer Research, International Cancer Research Foundation, William H. Donner Foundation: Cancer research: the official organ of the American Association for Cancer Research, Inc.. (1553285) Cancer research : the official organ of the American Association for Cancer Research, Inc., 1941. ISSN 0008-5472. Artikkelin verkkoversio. English
- ↑ a b ScienceDirect www.sciencedirect.com. Viitattu 22.3.2019.
- ↑ Snezana Kojic, Elisa Medeot, Ernesto Guccione, Helena Krmac, Ivano Zara, Valentina Martinelli: The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. Journal of Molecular Biology, 28.5.2004, nro 2, s. 313–325. PubMed:15136035. doi:10.1016/j.jmb.2004.03.071. ISSN 0022-2836. Artikkelin verkkoversio.
- ↑ Peter R. Mertens, Petra Lynen Jansen, Hans-Dieter Royer, Karsten Jürchott, Thomas Rauen, Björn Frye: Splicing Factor SRp30c Interaction with Y-box Protein-1 Confers Nuclear YB-1 Shuttling and Alternative Splice Site Selection. Journal of Biological Chemistry, 16.5.2003, nro 20, s. 18241–18248. PubMed:12604611. doi:10.1074/jbc.M212518200. ISSN 0021-9258. Artikkelin verkkoversio. en
- ↑ American Society of Biological Chemists, Rockefeller Institute for Medical Research, American Society for Biochemistry and Molecular Biology: The Journal of biological chemistry.. (1782222) The Journal of biological chemistry., 1905. ISSN 0021-9258. Artikkelin verkkoversio. English
- ↑ Ute Raffetseder, Björn Frye, Thomas Rauen, Karsten Jürchott, Hans-Dieter Royer, Petra Lynen Jansen: Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. The Journal of Biological Chemistry, 16.5.2003, nro 20, s. 18241–18248. PubMed:12604611. doi:10.1074/jbc.M212518200. ISSN 0021-9258. Artikkelin verkkoversio.
- ↑ Elena M. Klenova, Victor V. Lobanenkov, Ayman I. El-Kady, Angela Paul, Alexander F. Carne, Abigail F. Robinson: Physical and Functional Interaction between Two Pluripotent Proteins, the Y-box DNA/RNA-binding Factor, YB-1, and the Multivalent Zinc Finger Factor, CTCF. Journal of Biological Chemistry, 22.9.2000, nro 38, s. 29915–29921. PubMed:10906122. doi:10.1074/jbc.M001538200. ISSN 0021-9258. Artikkelin verkkoversio. en
- ↑ I. V. Chernukhin, S. Shamsuddin, A. F. Robinson, A. F. Carne, A. Paul, A. I. El-Kady: Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF. The Journal of Biological Chemistry, 22.9.2000, nro 38, s. 29915–29921. PubMed:10906122. doi:10.1074/jbc.M001538200. ISSN 0021-9258. Artikkelin verkkoversio.
- ↑ K. Kohno, M. Kuwano, T. Uchiumi, T. Ise, H. Takano, T. Imamura: Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression. Oncogene, 2000-12, nro 54, s. 6194–6202. doi:10.1038/sj.onc.1204029. ISSN 1476-5594. Artikkelin verkkoversio. en
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