Xylamine
Noradrenergic neurotoxin used in scientific research
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| Other names | N-2-Chloroethyl-N-ethyl-2-methylbenzylamine |
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| Formula | C12H18ClN |
| Molar mass | 211.73 g·mol−1 |
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Xylamine is a monoaminergic neurotoxin and benzylamine derivative that is closely related to DSP-4.[1][2] It is a relatively selective noradrenergic neurotoxin, which is attributed to its high affinity for the norepinephrine transporter (NET).[1] DSP-4 is generally preferred over xylamine for use in scientific research and hence xylamine is limitedly employed.[1] Xylamine was first described in 1975.[2][3]
References
- ^ a b c Kostrzewa RM (2022). "Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic Neurons". Handbook of Neurotoxicity. Cham: Springer International Publishing. pp. 159–198. doi:10.1007/978-3-031-15080-7_53. ISBN 978-3-031-15079-1.
- ^ a b Dudley MW, Howard BD, Cho AK (1990). "The interaction of the beta-haloethyl benzylamines, xylamine, and DSP-4 with catecholaminergic neurons". Annu Rev Pharmacol Toxicol. 30: 387–403. doi:10.1146/annurev.pa.30.040190.002131. PMID 2188573.
- ^ Krueger CA, Cook DA (November 1975). "Synthesis and adrenergic neuron blocking properties of some alkylating analogues of bretylium". Arch Int Pharmacodyn Ther. 218 (1): 96–105. PMID 1212016.
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See also: Receptor/signaling modulators • Adrenergics • Dopaminergics • Melatonergics • Serotonergics • Monoamine reuptake inhibitors • Monoamine releasing agents • Monoamine metabolism modulators
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