WNT3

Protein and coding gene in humans
WNT3
Identifiers
AliasesWNT3, INT4, TETAMS, Wnt family member 3
External IDsOMIM: 165330; MGI: 98955; HomoloGene: 22527; GeneCards: WNT3; OMA:WNT3 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for WNT3
Genomic location for WNT3
Band17q21.31-q21.32Start46,762,506 bp[1]
End46,833,154 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for WNT3
Genomic location for WNT3
Band11 E1|11 67.5 cMStart103,664,976 bp[2]
End103,708,783 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • hypothalamus

  • testicle

  • anterior cingulate cortex

  • skin of leg

  • right frontal lobe

  • dorsolateral prefrontal cortex

  • substantia nigra

  • right lobe of liver

  • gonad
Top expressed in
  • surface ectoderm

  • rhombic lip

  • labioscrotal swelling

  • lip

  • pretectal area

  • intestinal villus

  • Ileal epithelium

  • embryo

  • embryo

  • embryonic organizer
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • receptor ligand activity
  • protein domain specific binding
  • frizzled binding
  • protein binding
  • signaling receptor binding
Cellular component
  • cytoplasm
  • endocytic vesicle membrane
  • Wnt signalosome
  • endoplasmic reticulum lumen
  • plasma membrane
  • extracellular region
  • Golgi lumen
  • extracellular exosome
  • extracellular space
  • extracellular matrix
Biological process
  • cellular response to retinoic acid
  • cell fate commitment
  • Spemann organizer formation at the anterior end of the primitive streak
  • head morphogenesis
  • limb bud formation
  • mammary gland epithelium development
  • anatomical structure formation involved in morphogenesis
  • mesoderm formation
  • positive regulation of collateral sprouting in absence of injury
  • negative regulation of axon extension involved in axon guidance
  • dorsal/ventral axis specification
  • axon guidance
  • limb development
  • multicellular organism development
  • positive regulation of Wnt signaling pathway
  • gamete generation
  • canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
  • canonical Wnt signaling pathway involved in osteoblast differentiation
  • cell morphogenesis
  • canonical Wnt signaling pathway
  • anterior/posterior axis specification
  • embryonic forelimb morphogenesis
  • anterior/posterior pattern specification
  • embryonic hindlimb morphogenesis
  • Wnt signaling pathway
  • positive regulation of gene expression
  • regulation of neurogenesis
  • stem cell proliferation
  • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
  • canonical Wnt signaling pathway involved in stem cell proliferation
  • neuron differentiation
  • regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7473

22415

Ensembl

ENSG00000108379
ENSG00000277641
ENSG00000277626

ENSMUSG00000000125

UniProt

P56703

P17553

RefSeq (mRNA)

NM_030753

NM_009521

RefSeq (protein)

NP_110380

NP_033547

Location (UCSC)Chr 17: 46.76 – 46.83 MbChr 11: 103.66 – 103.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.[5][6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.[6]

References

  1. ^ a b c ENSG00000277641, ENSG00000277626 GRCh38: Ensembl release 89: ENSG00000108379, ENSG00000277641, ENSG00000277626 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000125 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics. 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
  6. ^ a b "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".

External links

  • GeneReviews/NIH/NCBI/UW entry on Tetra-Amelia Syndrome

Further reading

  • Nusse R, Brown A, Papkoff J, et al. (1991). "A new nomenclature for int-1 and related genes: the Wnt gene family". Cell. 64 (2): 231. doi:10.1016/0092-8674(91)90633-A. PMID 1846319. S2CID 3189574.
  • Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
  • Liu P, Wakamiya M, Shea MJ, et al. (1999). "Requirement for Wnt3 in vertebrate axis formation". Nat. Genet. 22 (4): 361–5. doi:10.1038/11932. PMID 10431240. S2CID 22195563.
  • Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084. S2CID 2009505.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Katoh M (2002). "Molecular cloning and characterization of human WNT3". Int. J. Oncol. 19 (5): 977–82. doi:10.3892/ijo.19.5.977. PMID 11604997.
  • Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Niemann S, Zhao C, Pascu F, et al. (2004). "Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family". Am. J. Hum. Genet. 74 (3): 558–63. doi:10.1086/382196. PMC 1182269. PMID 14872406.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chiba H, Kobune M, Kato J, et al. (2005). "Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells". Exp. Hematol. 32 (12): 1194–203. doi:10.1016/j.exphem.2004.08.010. PMID 15588944.
  • Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.


Stub icon

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e