Protein-coding gene in the species Homo sapiens
WIPI1 |
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Identifiers |
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Aliases | WIPI1, ATG18, ATG18A, WIPI49, WD repeat domain, phosphoinositide interacting 1 |
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External IDs | OMIM: 609224; MGI: 1261864; HomoloGene: 117983; GeneCards: WIPI1; OMA:WIPI1 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17q24.2 | Start | 68,420,948 bp[1] |
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End | 68,457,513 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11 E1|11 72.18 cM | Start | 109,464,157 bp[2] |
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End | 109,502,793 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - stromal cell of endometrium
- sperm
- gastrocnemius muscle
- minor salivary glands
- muscle of thigh
- biceps brachii
- left ventricle
- skeletal muscle tissue
- sural nerve
- olfactory zone of nasal mucosa
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| Top expressed in | - seminal vesicula
- interventricular septum
- saccule
- retinal pigment epithelium
- muscle of thigh
- right ventricle
- stroma of bone marrow
- submandibular gland
- otic vesicle
- granulocyte
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - phosphatidylinositol-3-phosphate binding
- phosphatidylinositol-3,5-bisphosphate binding
- androgen receptor binding
- signaling receptor binding
- estrogen receptor binding
- protein binding
- lipid binding
| Cellular component | - cytoplasm
- phagophore assembly site membrane
- endosome
- Golgi apparatus
- membrane
- Golgi membrane
- trans-Golgi network
- autophagosome membrane
- endosome membrane
- cytoskeleton
- cytoplasmic vesicle
- clathrin-coated vesicle
- phagophore assembly site
- cytosol
- extrinsic component of membrane
| Biological process | - vesicle targeting, trans-Golgi to endosome
- autophagy
- IRE1-mediated unfolded protein response
- macroautophagy
- autophagy of mitochondrion
- protein lipidation
- protein localization to phagophore assembly site
- autophagy of nucleus
- autophagosome assembly
- cellular response to starvation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 17: 68.42 – 68.46 Mb | Chr 11: 109.46 – 109.5 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.[5][6][7]
Structure and function
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein–protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.[5][7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000070540 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041895 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: WD repeat domain".
- ^ Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). "PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49". Mol. Biol. Cell. 15 (6): 2652–63. doi:10.1091/mbc.E03-10-0732. PMC 420090. PMID 15020712.
- ^ a b Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.
Further reading
- Chasman DI, Paré G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, Mälarstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM (November 2009). "Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis". PLOS Genet. 5 (11): e1000730. doi:10.1371/journal.pgen.1000730. PMC 2777390. PMID 19936222.
- Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010). "Network organization of the human autophagy system". Nature. 466 (7302): 68–76. Bibcode:2010Natur.466...68B. doi:10.1038/nature09204. PMC 2901998. PMID 20562859.
- Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (July 2007). "Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy". FEBS Lett. 581 (18): 3396–404. doi:10.1016/j.febslet.2007.06.040. PMID 17618624. S2CID 23430881.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.