VPS11

Protein-coding gene in the species Homo sapiens
VPS11
Identifiers
AliasesVPS11, END1, PEP5, RNF108, hHLD12, CORVET/HOPS core subunit, VPS11 core subunit of CORVET and HOPS complexes
External IDsOMIM: 608549; MGI: 1918982; HomoloGene: 6673; GeneCards: VPS11; OMA:VPS11 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for VPS11
Genomic location for VPS11
Band11q23.3Start119,067,692 bp[1]
End119,081,978 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for VPS11
Genomic location for VPS11
Band9|9 A5.2Start44,259,046 bp[2]
End44,272,967 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • prefrontal cortex

  • pituitary gland

  • apex of heart

  • right frontal lobe

  • anterior pituitary

  • right hemisphere of cerebellum

  • right adrenal gland

  • primary visual cortex

  • putamen

  • right adrenal cortex
Top expressed in
  • interventricular septum

  • granulocyte

  • neural layer of retina

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • primary visual cortex

  • ankle

  • muscle of thigh

  • cerebellar cortex

  • right kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein-macromolecule adaptor activity
  • protein domain specific binding
  • metal ion binding
  • protein binding
  • syntaxin binding
Cellular component
  • HOPS complex
  • endosome
  • late endosome
  • late endosome membrane
  • membrane
  • endocytic vesicle
  • autophagosome
  • lysosomal membrane
  • early endosome
  • lysosome
  • cytoplasmic vesicle
  • clathrin-coated vesicle
Biological process
  • endosomal vesicle fusion
  • regulation of protein stability
  • regulation of organelle assembly
  • positive regulation of protein targeting to mitochondrion
  • endosome to lysosome transport
  • autophagy
  • positive regulation of early endosome to late endosome transport
  • protein transport
  • intracellular protein transport
  • vesicle-mediated transport
  • regulation of SNARE complex assembly
  • lysosome organization
  • endosome organization
  • vesicle docking involved in exocytosis
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55823

71732

Ensembl

ENSG00000160695
ENSG00000280616

ENSMUSG00000032127

UniProt

Q9H270

Q91W86

RefSeq (mRNA)

NM_001290185
NM_021729

NM_027889
NM_001357393

RefSeq (protein)
NP_001277114
NP_068375
NP_001365147
NP_001365148
NP_001365149

NP_001365150

NP_082165
NP_001344322

Location (UCSC)Chr 11: 119.07 – 119.08 MbChr 9: 44.26 – 44.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.[5]

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[5]

Interactions

VPS11 has been shown to interact with VPS18,[6] VPS33A[6] and STX7.[6]

References

  1. ^ a b c ENSG00000280616 GRCh38: Ensembl release 89: ENSG00000160695, ENSG00000280616 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032127 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)".
  6. ^ a b c Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Huizing M, Didier A, Walenta J, Anikster Y, Gahl WA, Krämer H (2001). "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33". Gene. 264 (2): 241–7. doi:10.1016/S0378-1119(01)00333-X. PMID 11250079.
  • Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.
  • Kim BY, Ueda M, Kominami E, Akagawa K, Kohsaka S, Akazawa C (2004). "Identification of mouse Vps16 and biochemical characterization of mammalian class C Vps complex". Biochem. Biophys. Res. Commun. 311 (3): 577–82. doi:10.1016/j.bbrc.2003.10.030. PMID 14623309.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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