VMP1

Protein-coding gene in the species Homo sapiens

VMP1
Identifiers
AliasesVMP1, EPG3, TANGO5, TMEM49, vacuole membrane protein 1
External IDsOMIM: 611753; MGI: 1923159; HomoloGene: 23686; GeneCards: VMP1; OMA:VMP1 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for VMP1
Genomic location for VMP1
Band17q23.1Start59,707,192 bp[1]
End59,842,255 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for VMP1
Genomic location for VMP1
Band11|11 CStart86,474,691 bp[2]
End86,574,662 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • monocyte

  • epithelium of colon

  • gallbladder

  • rectum

  • mucosa of urinary bladder

  • islet of Langerhans

  • pericardium

  • upper lobe of left lung

  • appendix
Top expressed in
  • epithelium of small intestine

  • stroma of bone marrow

  • gastrula

  • lobe of prostate

  • jejunum

  • yolk sac

  • ileum

  • duodenum

  • decidua

  • lacrimal gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • vacuolar membrane
  • integral component of membrane
  • vacuole
  • plasma membrane
  • autophagosome membrane
  • nucleolus
  • endoplasmic reticulum
  • membrane
  • phagophore assembly site
  • endoplasmic reticulum-Golgi intermediate compartment membrane
Biological process
  • autophagy
  • cell adhesion
  • Golgi organization
  • embryo implantation
  • endoplasmic reticulum organization
  • exocytosis
  • cell junction assembly
  • cell-cell adhesion
  • autophagosome assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81671

75909

Ensembl

ENSG00000062716

ENSMUSG00000018171

UniProt

Q96GC9

Q99KU0

RefSeq (mRNA)
NM_001329394
NM_001329395
NM_001329396
NM_001329397
NM_001329398

NM_001329399
NM_001329400
NM_001329401
NM_001329402
NM_030938

NM_029478
NM_001356531
NM_001379040
NM_001379041

RefSeq (protein)
NP_001316323
NP_001316324
NP_001316325
NP_001316326
NP_001316327

NP_001316328
NP_001316329
NP_001316330
NP_001316331
NP_112200

NP_083754
NP_001343460
NP_001365969
NP_001365970

Location (UCSC)Chr 17: 59.71 – 59.84 MbChr 11: 86.47 – 86.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuole membrane protein 1 is a protein that in humans is encoded by the VMP1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000062716 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018171 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ Dusetti NJ, Jiang Y, Vaccaro MI, Tomasini R, Azizi Samir A, Calvo EL, Ropolo A, Fiedler F, Mallo GV, Dagorn JC, Iovanna JL (Jan 2002). "Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation". Biochem Biophys Res Commun. 290 (2): 641–9. doi:10.1006/bbrc.2001.6244. PMID 11785947.
  7. ^ "VMP1 vacuole membrane protein 1 [ Homo sapiens (human) ]".

Further reading

  • Ropolo A, Grasso D, Pardo R, et al. (2008). "The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells". J. Biol. Chem. 282 (51): 37124–33. doi:10.1074/jbc.M706956200. PMID 17940279.
  • Sauermann M, Sahin O, Sültmann H, et al. (2008). "Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cells". Oncogene. 27 (9): 1320–6. doi:10.1038/sj.onc.1210743. PMID 17724469. S2CID 1805602.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Starkuviene V, Liebel U, Simpson JC, et al. (2004). "High-content screening microscopy identifies novel proteins with a putative role in secretory membrane traffic". Genome Res. 14 (10A): 1948–56. doi:10.1101/gr.2658304. PMC 524419. PMID 15466293.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.


  • v
  • t
  • e