Protein-coding gene in the species Homo sapiens
| VAV2 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ |
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| Identifiers |
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| Aliases | VAV2, VAV-2, vav guanine nucleotide exchange factor 2 |
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| External IDs | OMIM: 600428; MGI: 102718; HomoloGene: 2530; GeneCards: VAV2; OMA:VAV2 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 9 (human)[1] |
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| | Band | 9q34.2 | Start | 133,761,894 bp[1] |
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| End | 133,992,604 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 2 (mouse)[2] |
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| | Band | 2 A3|2 19.36 cM | Start | 27,152,116 bp[2] |
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| End | 27,317,045 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - parotid gland
- ganglionic eminence
- ventricular zone
- body of pancreas
- right lobe of liver
- caput epididymis
- right adrenal cortex
- corpus epididymis
- left adrenal cortex
- jejunal mucosa
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| | Top expressed in | - habenula
- mesenteric lymph nodes
- lumbar spinal ganglion
- medullary collecting duct
- seminal vesicula
- cumulus cell
- seminiferous tubule
- conjunctival fornix
- ganglionic eminence
- molar
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | - guanyl-nucleotide exchange factor activity
- epidermal growth factor receptor binding
- metal ion binding
- protein binding
- phosphotyrosine residue binding
| | Cellular component | - cytoplasm
- cytosol
- plasma membrane
| | Biological process | - regulation of cell size
- intracellular signal transduction
- Fc-gamma receptor signaling pathway involved in phagocytosis
- regulation of GTPase activity
- ephrin receptor signaling pathway
- positive regulation of phosphatidylinositol 3-kinase activity
- platelet activation
- Fc-epsilon receptor signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- cell projection assembly
- angiogenesis
- positive regulation of apoptotic process
- regulation of Rho protein signal transduction
- regulation of small GTPase mediated signal transduction
- cell migration
- signal transduction
- lamellipodium assembly
- small GTPase mediated signal transduction
- G protein-coupled receptor signaling pathway
| | Sources:Amigo / QuickGO |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.[5][6]
VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.[6]
Interactions
VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation.[7] Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1[7] and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity.[7] VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner[8] and interact with CD19[9] and Grb2.[10][11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000160293 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009621 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Henske EP, Short MP, Jozwiak S, Bovey CM, Ramlakhan S, Haines JL, Kwiatkowski DJ (June 1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet. 59 (Pt 1): 25–37. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982. S2CID 27548854.
- ^ a b "Entrez Gene: VAV2 vav 2 oncogene".
- ^ a b c Marignani PA, Kanai F (2001-07-09). "Vav2 is required for cell spreading". The Journal of Cell Biology. 154 (1): 177–186. doi:10.1083/jcb.200103134. ISSN 0021-9525. PMC 2196856. PMID 11448999.
- ^ Arora PD, Marignani PA, McCulloch CA (July 2008). "Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2". American Journal of Physiology. Cell Physiology. 295 (1): C130–C137. doi:10.1152/ajpcell.00168.2008. ISSN 0363-6143. PMC 2493554. PMID 18434624.
- ^ Doody GM, Billadeau D D, Clayton E, Hutchings A, Berland R, McAdam S, Leibson P J, Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMC 305817. PMID 11080163.
- ^ Blagoev B, Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.
- ^ Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton P A, Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575.
Further reading
- Romero F, Fischer S (1997). "Structure and function of vav". Cell. Signal. 8 (8): 545–53. doi:10.1016/S0898-6568(96)00118-0. PMID 9115846.
- Smit L, van der Horst G, Borst J (1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors". J. Biol. Chem. 271 (15): 8564–9. doi:10.1074/jbc.271.15.8564. PMID 8621483.
- Tamma SM, Chirmule N, Yagura H, et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood. 90 (4): 1588–93. doi:10.1182/blood.V90.4.1588. PMID 9269777.
- De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMC 1171183. PMID 10022833.
- Pandey A, Podtelejnikov AV, Blagoev B, et al. (2000). "Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 179–84. Bibcode:2000PNAS...97..179P. doi:10.1073/pnas.97.1.179. PMC 26636. PMID 10618391.
- Moores SL, Selfors LM, Fredericks J, et al. (2000). "Vav family proteins couple to diverse cell surface receptors". Mol. Cell. Biol. 20 (17): 6364–73. doi:10.1128/MCB.20.17.6364-6373.2000. PMC 86111. PMID 10938113.
- Liu BP, Burridge K (2000). "Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins". Mol. Cell. Biol. 20 (19): 7160–9. doi:10.1128/MCB.20.19.7160-7169.2000. PMC 86269. PMID 10982832.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Doody GM, Billadeau DD, Clayton E, et al. (2001). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. PMC 305817. PMID 11080163.
- Tartare-Deckert S, Monthouel MN, Charvet C, et al. (2001). "Vav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyte". J. Biol. Chem. 276 (24): 20849–57. doi:10.1074/jbc.M010588200. PMID 11262396.
- Teckchandani AM, Feshchenko EA, Tsygankov AY (2001). "c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases". Oncogene. 20 (14): 1739–55. doi:10.1038/sj.onc.1204246. PMID 11313921. S2CID 28410819.
- Jevremovic D, Billadeau DD, Schoon RA, et al. (2001). "Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2". J. Immunol. 166 (12): 7219–28. doi:10.4049/jimmunol.166.12.7219. PMID 11390470.
- Marignani PA, Carpenter CL (2001). "Vav2 is required for cell spreading". J. Cell Biol. 154 (1): 177–86. doi:10.1083/jcb.200103134. PMC 2196856. PMID 11448999.
- Tamás P, Solti Z, Buday L (2001). "Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor". Cell. Signal. 13 (7): 475–81. doi:10.1016/S0898-6568(01)00172-3. PMID 11516622.
- Bourguignon LY, Zhu H, Zhou B, et al. (2002). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. PMID 11606575.
- Booden MA, Campbell SL, Der CJ (2002). "Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation". Mol. Cell. Biol. 22 (8): 2487–97. doi:10.1128/MCB.22.8.2487-2497.2002. PMC 133724. PMID 11909943.
- Tamás P, Solti Z, Bauer P, et al. (2003). "Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac". J. Biol. Chem. 278 (7): 5163–71. doi:10.1074/jbc.M207555200. PMID 12454019.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
External links
- Overview of all the structural information available in the PDB for UniProt: P52735 (Guanine nucleotide exchange factor VAV2) at the PDBe-KB.
 | This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it. |
2dlz: Solution structure of the SH2 domain of human protein vav-2
2dm1: Solution structure of the second SH3 domain of human protein vav-2
